Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats.
Li T, Shen Y, Lin F, Fu W, Liu S, Wang C, Liang J, Fan X, Ye X, Tang Y, Ding M, Yang Y, Lei C, Hu S.
Li T, et al. Among authors: fu w.
FASEB J. 2019 Jun;33(6):7467-7478. doi: 10.1096/fj.201802354R. Epub 2019 Mar 18.
FASEB J. 2019.
PMID: 30885011
Our results provide preclinical experimental evidence that the cardiac expression of RyR2 nanobodies with AAV9 vectors is a promising therapeutic strategy for HF.-Li, T., Shen, Y., Lin, F., Fu, W., Liu, S., Wang, C., Liang, J., Fan, X., Ye, X., Tang, Y., Ding, M., Y …
Our results provide preclinical experimental evidence that the cardiac expression of RyR2 nanobodies with AAV9 vectors is a promising therap …