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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: puschel k. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19.
Casagrande M, Fitzek A, Spitzer MS, Püschel K, Glatzel M, Krasemann S, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M. Casagrande M, et al. Among authors: puschel k. JAMA Ophthalmol. 2021 Apr 1;139(4):383-388. doi: 10.1001/jamaophthalmol.2020.6339. JAMA Ophthalmol. 2021. PMID: 33475692 Free PMC article.
The handling of SARS-CoV-2 associated deaths - infectivity of the body.
Schröder AS, Edler C, Ondruschka B, Püschel K, Schädler J, Heinemann A, Heinrich F, Lütgehetmann M, Pfefferle S, Aepfelbacher M, Fitzek A, Sperhake JP. Schröder AS, et al. Among authors: puschel k. Forensic Sci Med Pathol. 2021 Sep;17(3):411-418. doi: 10.1007/s12024-021-00379-9. Epub 2021 Jun 2. Forensic Sci Med Pathol. 2021. PMID: 34076852 Free PMC article.
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.
Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, Püschel K, Krasemann S, Aepfelbacher M, Glatzel M. Matschke J, et al. Among authors: puschel k. Lancet Neurol. 2020 Nov;19(11):919-929. doi: 10.1016/S1474-4422(20)30308-2. Epub 2020 Oct 5. Lancet Neurol. 2020. PMID: 33031735 Free PMC article.
No difference in the prevalence of Alzheimer-type neurodegenerative changes in the brains of suicides when compared with controls: an explorative neuropathologic study.
Matschke J, Sehner S, Gallinat J, Siegers J, Murroni M, Püschel K, Glatzel M. Matschke J, et al. Among authors: puschel k. Eur Arch Psychiatry Clin Neurosci. 2018 Aug;268(5):509-517. doi: 10.1007/s00406-018-0876-4. Epub 2018 Jan 30. Eur Arch Psychiatry Clin Neurosci. 2018. PMID: 29383449
701 results