Pirazzini M - Search Results

1

Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice.

Pirazzini M, Grinzato A, Corti D, Barbieri S, Leka O, Vallese F, Tonellato M, Silacci-Fregni C, Piccoli L, Kandiah E, Schiavo G, Zanotti G, Lanzavecchia A, Montecucco C. Pirazzini M, et al. J Clin Invest. 2021 Nov 15;131(22):e151676. doi: 10.1172/JCI151676. J Clin Invest. 2021. PMID: 34618682 Free PMC article.

2

Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca²⁺ accumulation in spinobulbar muscular atrophy skeletal muscle.

Marchioretti C, Zanetti G, Pirazzini M, Gherardi G, Nogara L, Andreotti R, Martini P, Marcucci L, Canato M, Nath SR, Zuccaro E, Chivet M, Mammucari C, Pacifici M, Raffaello A, Rizzuto R, Mattarei A, Desbats MA, Salviati L, Megighian A, Sorarù G, Pegoraro E, Belluzzi E, Pozzuoli A, Biz C, Ruggieri P, Romualdi C, Lieberman AP, Babu GJ, Sandri M, Blaauw B, Basso M, Pennuto M. Marchioretti C, et al. Among authors: pirazzini m. Nat Commun. 2023 Feb 6;14(1):602. doi: 10.1038/s41467-023-36185-w. Nat Commun. 2023. PMID: 36746942 Free PMC article.

3

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

Pirazzini M, Rossetto O, Bolognese P, Shone CC, Montecucco C. Pirazzini M, et al. Cell Microbiol. 2011 Nov;13(11):1731-43. doi: 10.1111/j.1462-5822.2011.01654.x. Epub 2011 Aug 25. Cell Microbiol. 2011. PMID: 21790947

4

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C. Pirazzini M, et al. FEBS Lett. 2013 Jan 16;587(2):150-5. doi: 10.1016/j.febslet.2012.11.007. Epub 2012 Nov 21. FEBS Lett. 2013. PMID: 23178719 Free article.

5

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.

Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C. Pirazzini M, et al. Biochem Biophys Res Commun. 2013 Jan 4;430(1):38-42. doi: 10.1016/j.bbrc.2012.11.048. Epub 2012 Nov 27. Biochem Biophys Res Commun. 2013. PMID: 23200837

6

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

Eleopra R, Montecucco C, Devigili G, Lettieri C, Rinaldo S, Verriello L, Pirazzini M, Caccin P, Rossetto O. Eleopra R, et al. Among authors: pirazzini m. Clin Neurophysiol. 2013 May;124(5):999-1004. doi: 10.1016/j.clinph.2012.11.004. Epub 2012 Dec 13. Clin Neurophysiol. 2013. PMID: 23245668

7

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T. Pirazzini M, et al. FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21. FEBS Lett. 2013. PMID: 24157364 Free article.

8

Diphtheria toxin conformational switching at acidic pH.

Leka O, Vallese F, Pirazzini M, Berto P, Montecucco C, Zanotti G. Leka O, et al. Among authors: pirazzini m. FEBS J. 2014 May;281(9):2115-22. doi: 10.1111/febs.12783. Epub 2014 Apr 1. FEBS J. 2014. PMID: 24628974 Free article.

9

Botulinum neurotoxins: genetic, structural and mechanistic insights.

Rossetto O, Pirazzini M, Montecucco C. Rossetto O, et al. Among authors: pirazzini m. Nat Rev Microbiol. 2014 Aug;12(8):535-49. doi: 10.1038/nrmicro3295. Epub 2014 Jun 30. Nat Rev Microbiol. 2014. PMID: 24975322 Review.

10

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C. Pirazzini M, et al. Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15. Cell Rep. 2014. PMID: 25220457 Free article.

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