Huth F - Search Results

1

Pharmacokinetics of Asciminib When Taken With Imatinib or With Food.

Hoch M, Zack J, Quinlan M, Huth F, Forte S, Dodd S, Aimone P, Hourcade-Potelleret F. Hoch M, et al. Among authors: huth f. Clin Pharmacol Drug Dev. 2022 Feb;11(2):207-219. doi: 10.1002/cpdd.1019. Epub 2021 Oct 5. Clin Pharmacol Drug Dev. 2022. PMID: 34609077

2

Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.

Samant TS, Dhuria S, Lu Y, Laisney M, Yang S, Grandeury A, Mueller-Zsigmondy M, Umehara K, Huth F, Miller M, Germa C, Elmeliegy M. Samant TS, et al. Among authors: huth f. Clin Pharmacol Ther. 2018 Aug;104(2):374-383. doi: 10.1002/cpt.940. Epub 2017 Dec 8. Clin Pharmacol Ther. 2018. PMID: 29134635 Free PMC article. Clinical Trial.

3

Siponimod pharmacokinetics, safety, and tolerability in combination with rifampin, a CYP2C9/3A4 inducer, in healthy subjects.

Gardin A, Gray C, Neelakantham S, Huth F, Davidson AM, Dumitras S, Legangneux E, Shakeri-Nejad K. Gardin A, et al. Among authors: huth f. Eur J Clin Pharmacol. 2018 Dec;74(12):1593-1604. doi: 10.1007/s00228-018-2533-2. Epub 2018 Aug 13. Eur J Clin Pharmacol. 2018. PMID: 30105453

4

Siponimod pharmacokinetics, safety, and tolerability in combination with the potent CYP3A4 inhibitor itraconazole in healthy subjects with different CYP2C9 genotypes.

Gardin A, Shakeri-Nejad K, Feller A, Huth F, Neelakantham S, Dumitras S. Gardin A, et al. Among authors: huth f. Eur J Clin Pharmacol. 2019 Nov;75(11):1565-1574. doi: 10.1007/s00228-019-02729-7. Epub 2019 Aug 7. Eur J Clin Pharmacol. 2019. PMID: 31392364 Clinical Trial.

5

Ribociclib Drug-Drug Interactions: Clinical Evaluations and Physiologically-Based Pharmacokinetic Modeling to Guide Drug Labeling.

Samant TS, Huth F, Umehara K, Schiller H, Dhuria SV, Elmeliegy M, Miller M, Chakraborty A, Heimbach T, He H, Ji Y. Samant TS, et al. Among authors: huth f. Clin Pharmacol Ther. 2020 Sep;108(3):575-585. doi: 10.1002/cpt.1950. Epub 2020 Jul 25. Clin Pharmacol Ther. 2020. PMID: 32557601 Clinical Trial.

6

A kinase inhibitor which specifically targets the ABL myristate pocket (STAMP), but unlike asciminib crosses the blood-brain barrier.

Manley PW, Huth F, Moussaoui S, Schoepfer J. Manley PW, et al. Among authors: huth f. Bioorg Med Chem Lett. 2022 Mar 1;59:128577. doi: 10.1016/j.bmcl.2022.128577. Epub 2022 Jan 19. Bioorg Med Chem Lett. 2022. PMID: 35065232

7

Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents.

Hoch M, Huth F, Sato M, Sengupta T, Quinlan M, Dodd S, Kapoor S, Hourcade-Potelleret F. Hoch M, et al. Among authors: huth f. Clin Transl Sci. 2022 Jul;15(7):1698-1712. doi: 10.1111/cts.13285. Epub 2022 May 26. Clin Transl Sci. 2022. PMID: 35616006 Free PMC article.

8

Use of Pharmacokinetic and Pharmacodynamic Data to Develop the CDK4/6 Inhibitor Ribociclib for Patients with Advanced Breast Cancer.

Ji Y, Schiller H, Yang S, Quinlan M, Darstein C, Huth F, Winter S, Chakraborty A. Ji Y, et al. Among authors: huth f. Clin Pharmacokinet. 2024 Feb;63(2):155-170. doi: 10.1007/s40262-023-01338-z. Epub 2024 Jan 20. Clin Pharmacokinet. 2024. PMID: 38244190 Free PMC article. Review.

9

Drug-drug interactions of icenticaftor (QBW251) with a 5-probe cytochrome P450 cocktail and oral contraceptives.

Huth F, Glaenzel U, Drollmann A, Weis W, Zack J, Bebrevska L. Huth F, et al. Clin Transl Sci. 2024 Sep;17(9):e70028. doi: 10.1111/cts.70028. Clin Transl Sci. 2024. PMID: 39288032 Free PMC article. Clinical Trial.

10

Clinical Pharmacology of Asciminib: A Review.

Hoch M, Huth F, Manley PW, Loisios-Konstantinidis I, Combes FP, Li YF, Fu Y, Sy SKB, Obourn V, Chakraborty A, Hourcade-Potelleret F. Hoch M, et al. Among authors: huth f. Clin Pharmacokinet. 2024 Nov;63(11):1513-1528. doi: 10.1007/s40262-024-01428-6. Epub 2024 Oct 29. Clin Pharmacokinet. 2024. PMID: 39467980 Free PMC article. Review.

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