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A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.
Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS. Connolly KA, et al. Among authors: cheung jf. Sci Immunol. 2021 Oct;6(64):eabg7836. doi: 10.1126/sciimmunol.abg7836. Epub 2021 Sep 2. Sci Immunol. 2021. PMID: 34597124 Free PMC article.
Inducible de novo expression of neoantigens in tumor cells and mice.
Damo M, Fitzgerald B, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, Cui C, Monroy I, Gokare P, Cabeceiras P, Jacks T, Joshi NS. Damo M, et al. Among authors: cheung jf. Nat Biotechnol. 2021 Jan;39(1):64-73. doi: 10.1038/s41587-020-0613-1. Epub 2020 Jul 27. Nat Biotechnol. 2021. PMID: 32719479 Free PMC article.
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory.
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. Micevic G, et al. Among authors: cheung jf. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2304319120. doi: 10.1073/pnas.2304319120. Epub 2023 Jul 17. Proc Natl Acad Sci U S A. 2023. PMID: 37459511 Free PMC article.
A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells.
Calvo V, Zheng W, Adam-Artigues A, Staschke KA, Huang X, Cheung JF, Nobre AR, Fujisawa S, Liu D, Fumagalli M, Surguladze D, Stokes ME, Nowacek A, Mulvihill M, Farias EF, Aguirre-Ghiso JA. Calvo V, et al. Among authors: cheung jf. Clin Cancer Res. 2023 Dec 15;29(24):5155-5172. doi: 10.1158/1078-0432.CCR-23-1427. Clin Cancer Res. 2023. PMID: 37982738 Free PMC article.
Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGFβ2.
Nobre AR, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, Aguirre-Ghiso JA. Nobre AR, et al. Among authors: cheung jf. Nat Cancer. 2021 Mar;2(3):327-339. doi: 10.1038/s43018-021-00179-8. Epub 2021 Mar 11. Nat Cancer. 2021. PMID: 34993493 Free PMC article.
Corrigendum: Mechanism of early dissemination and metastasis in Her2+ mammary cancer.
Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Harper KL, et al. Among authors: cheung jf. Nature. 2018 Jan 18;553(7688):366. doi: 10.1038/nature24666. Epub 2017 Dec 13. Nature. 2018. PMID: 29236689 Free PMC article.
Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.
Fluegen G, Avivar-Valderas A, Wang Y, Padgen MR, Williams JK, Nobre AR, Calvo V, Cheung JF, Bravo-Cordero JJ, Entenberg D, Castracane J, Verkhusha V, Keely PJ, Condeelis J, Aguirre-Ghiso JA. Fluegen G, et al. Among authors: cheung jf. Nat Cell Biol. 2017 Feb;19(2):120-132. doi: 10.1038/ncb3465. Epub 2017 Jan 23. Nat Cell Biol. 2017. PMID: 28114271 Free PMC article.
15 results