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Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM. Luchetti G, et al. Among authors: dixit vm. Cell Host Microbe. 2021 Oct 13;29(10):1521-1530.e10. doi: 10.1016/j.chom.2021.08.010. Epub 2021 Sep 6. Cell Host Microbe. 2021. PMID: 34492225 Free PMC article.
Cryopyrin activates the inflammasome in response to toxins and ATP.
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Mariathasan S, et al. Among authors: dixit vm. Nature. 2006 Mar 9;440(7081):228-32. doi: 10.1038/nature04515. Epub 2006 Jan 11. Nature. 2006. PMID: 16407890
333 results