Lacombe O - Search Results

1

The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis.

Derrett-Smith E, Clark KEN, Shiwen X, Abraham DJ, Hoyles RK, Lacombe O, Broqua P, Junien JL, Konstantinova I, Ong VH, Denton CP. Derrett-Smith E, et al. Among authors: lacombe o. Arthritis Res Ther. 2021 Sep 6;23(1):234. doi: 10.1186/s13075-021-02592-x. Arthritis Res Ther. 2021. PMID: 34488870 Free PMC article.

2

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.

Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, Jacquier E, Gauthier E, Lepais V, Chatar M, Ferry S, Thourigny A, Guillier F, Llacer J, Amaudrut J, Dodey P, Lacombe O, Masson P, Montalbetti C, Wettstein G, Luccarini JM, Legendre C, Junien JL, Broqua P. Boubia B, et al. Among authors: lacombe o. J Med Chem. 2018 Mar 22;61(6):2246-2265. doi: 10.1021/acs.jmedchem.7b01285. Epub 2018 Feb 27. J Med Chem. 2018. PMID: 29446942

3

Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models.

Entchev E, Jantzen I, Masson P, Bocart S, Bournique B, Luccarini JM, Bouchot A, Lacombe O, Junien JL, Broqua P, Tallandier M. Entchev E, et al. Among authors: lacombe o. PLoS One. 2020 May 15;15(5):e0233032. doi: 10.1371/journal.pone.0233032. eCollection 2020. PLoS One. 2020. PMID: 32413051 Free PMC article.

4

MPS VI associated ocular phenotypes in an MPS VI murine model and the therapeutic effects of odiparcil treatment.

Entchev E, Antonelli S, Mauro V, Cimbolini N, Jantzen I, Roussey A, Germain JM, Zhang H, Luccarrini JM, Lacombe O, Young SP, Feraille L, Tallandier M. Entchev E, et al. Among authors: lacombe o. Mol Genet Metab. 2022 Feb;135(2):143-153. doi: 10.1016/j.ymgme.2021.07.008. Epub 2021 Jul 25. Mol Genet Metab. 2022. PMID: 34417096 Free article.

5

Oral treatment for mucopolysaccharidosis VI: Outcomes of the first phase IIa study with odiparcil.

Guffon N, Chowdary P, Teles EL, Hughes D, Hennermann JB, Huot-Marchand P, Faudot-Vernier E, Lacombe O, Fiquet A, Richard MP, Abitbol JL, Tallandier M, Hendriksz CJ. Guffon N, et al. Among authors: lacombe o. J Inherit Metab Dis. 2022 Mar;45(2):340-352. doi: 10.1002/jimd.12467. Epub 2021 Dec 30. J Inherit Metab Dis. 2022. PMID: 34910312 Clinical Trial.

6

In vitro primary human and animal cell-based blood-brain barrier models as a screening tool in drug discovery.

Lacombe O, Videau O, Chevillon D, Guyot AC, Contreras C, Blondel S, Nicolas L, Ghettas A, Bénech H, Thevenot E, Pruvost A, Bolze S, Krzaczkowski L, Prévost C, Mabondzo A. Lacombe O, et al. Mol Pharm. 2011 Jun 6;8(3):651-63. doi: 10.1021/mp1004614. Epub 2011 Apr 15. Mol Pharm. 2011. PMID: 21438632

7

Localisation of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes.

Lacombe O, Woodley J, Solleux C, Delbos JM, Boursier-Neyret C, Houin G. Lacombe O, et al. Eur J Pharm Sci. 2004 Dec;23(4-5):385-91. doi: 10.1016/j.ejps.2004.09.002. Eur J Pharm Sci. 2004. PMID: 15567292

8

Liquid chromatographic-mass spectrometric method to assess cytochrome P450-mediated metabolism of testosterone by rat everted gut sacs.

Arellano C, Philibert C, Lacombe O, Woodley J, Houin G. Arellano C, et al. Among authors: lacombe o. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Aug 5;807(2):263-70. doi: 10.1016/j.jchromb.2004.04.015. J Chromatogr B Analyt Technol Biomed Life Sci. 2004. PMID: 15203039

9

Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs.

Arellano C, Philibert C, Dane à Yakan EN, Vachoux C, Lacombe O, Woodley J, Houin G. Arellano C, et al. Among authors: lacombe o. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 May 5;819(1):105-13. doi: 10.1016/j.jchromb.2005.01.036. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15797528

10

The perfused everted intestinal segment of rat. 1st communication: absorption kinetics of markers of different permeation mechanisms.

Gandia P, Lacombe O, Woodley J, Houin G. Gandia P, et al. Among authors: lacombe o. Arzneimittelforschung. 2004;54(8):467-73. doi: 10.1055/s-0031-1297000. Arzneimittelforschung. 2004. PMID: 15460214

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