Wang J - Search Results

1

Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function.

Sane R, Malhi V, Sutaria DS, Cho E, Twomey P, Craggs C, Wang J, Harris A, Musib L. Sane R, et al. Among authors: wang j. J Clin Pharmacol. 2022 Feb;62(2):171-181. doi: 10.1002/jcph.1941. Epub 2021 Dec 23. J Clin Pharmacol. 2022. PMID: 34402068 Free PMC article. Clinical Trial.

2

A phase 1, randomized study to evaluate safety, tolerability, and pharmacokinetics of GDC-3280, a potential novel anti-fibrotic small molecule, in healthy subjects.

Cheung D, Fong A, Ding HT, Cabanski CR, Wang J, Chen Y, Bush J, Harris JM, Pan L. Cheung D, et al. Among authors: wang j. Pulm Pharmacol Ther. 2021 Aug;69:102051. doi: 10.1016/j.pupt.2021.102051. Epub 2021 Jun 21. Pulm Pharmacol Ther. 2021. PMID: 34166834 Free article. Clinical Trial.

3

Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.

Malhi V, Agarwal P, Gates MR, Liu L, Wang J, De Bruyn T, Lam S, Eng-Wong J, Perez-Moreno P, Chen YC, Yu J. Malhi V, et al. Among authors: wang j. Cancer Res Commun. 2023 Dec 15;3(12):2551-2559. doi: 10.1158/2767-9764.CRC-23-0324. Cancer Res Commun. 2023. PMID: 38019116 Free PMC article. Clinical Trial.

4

A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers.

Pan L, Belloni P, Ding HT, Wang J, Rubino CM, Putnam WS. Pan L, et al. Among authors: wang j. Adv Ther. 2017 Sep;34(9):2071-2082. doi: 10.1007/s12325-017-0594-8. Epub 2017 Aug 14. Adv Ther. 2017. PMID: 28808905 Free PMC article. Clinical Trial.

5

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.

Mao J, Fan P, Wong S, Wang J, Ismaili MHA, Dean B, Hop CECA, Wright M, Chen Y. Mao J, et al. Among authors: wang j. Pharm Res. 2017 Nov;34(11):2403-2414. doi: 10.1007/s11095-017-2246-8. Epub 2017 Aug 16. Pharm Res. 2017. PMID: 28815392

6

Exploring the potential of dried plasma collection cards for liquid chromatography coupled with tandem mass spectrometry quantitation of giredestrant in human plasma.

Tang Y, Chen L, Liang X, Dean B, Wang J. Tang Y, et al. Among authors: wang j. Biomed Chromatogr. 2023 Mar;37(3):e5554. doi: 10.1002/bmc.5554. Epub 2022 Dec 5. Biomed Chromatogr. 2023. PMID: 36417291

7

Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery.

Zhang X, Ding X, Wang J, Dean B. Zhang X, et al. Among authors: wang j. J Pharm Biomed Anal. 2019 Feb 5;164:62-69. doi: 10.1016/j.jpba.2018.10.021. Epub 2018 Oct 13. J Pharm Biomed Anal. 2019. PMID: 30359840

8

A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.

Wang S, Chen B, Dragovich P, Pillow T, Staben L, Guo J, Su D, Zhang C, Bobba S, Ma Y, Wang J, Sangaraju D, Wei B, Phillips GL, Khojasteh C, Zhang D. Wang S, et al. Among authors: wang j. Drug Metab Dispos. 2019 May;47(5):547-555. doi: 10.1124/dmd.118.085209. Epub 2019 Mar 11. Drug Metab Dispos. 2019. PMID: 30858239

9

Volumetric absorptive microsampling-LC-MS/MS assays for quantitation of giredestrant in dried human whole blood.

Johnson R, Rehmani I, Leahy M, Walker A, Liang X, Dean B, Wang J. Johnson R, et al. Among authors: wang j. Bioanalysis. 2022 Nov;14(21):1377-1389. doi: 10.4155/bio-2022-0189. Epub 2023 Jan 19. Bioanalysis. 2022. PMID: 36655682

10

Determination of a novel antifibrotic small molecule GDC-3280 in human plasma and urine by liquid chromatography tandem mass spectrometry to support its first-in-human clinical trial.

Wang J, Van Parys M, Pan L, Chen Y, Cheung D, McKnight J, Milanowski D, Ding X, Dean B. Wang J, et al. Biomed Chromatogr. 2019 Apr;33(4):e4482. doi: 10.1002/bmc.4482. Epub 2019 Feb 15. Biomed Chromatogr. 2019. PMID: 30618197 Clinical Trial.

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