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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. Orellana EA, et al. Among authors: zhang w. Mol Cell. 2021 Aug 19;81(16):3323-3338.e14. doi: 10.1016/j.molcel.2021.06.031. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352207 Free PMC article.
Targeting noncoding RNAs in disease.
Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Adams BD, et al. J Clin Invest. 2017 Mar 1;127(3):761-771. doi: 10.1172/JCI84424. Epub 2017 Mar 1. J Clin Invest. 2017. PMID: 28248199 Free PMC article. Review.
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. Choe J, et al. Among authors: zhang w. Nature. 2018 Sep;561(7724):556-560. doi: 10.1038/s41586-018-0538-8. Epub 2018 Sep 19. Nature. 2018. PMID: 30232453 Free PMC article.
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