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Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D. Dodagatta-Marri E, et al. Among authors: yang s, yang b. Cell Rep. 2021 Jul 6;36(1):109309. doi: 10.1016/j.celrep.2021.109309. Cell Rep. 2021. PMID: 34233193 Free PMC article.
A larger target leads to faster evolution.
Yang B, Rifkin SA. Yang B, et al. Elife. 2020 Oct 14;9:e62689. doi: 10.7554/eLife.62689. Elife. 2020. PMID: 33052100 Free PMC article.
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