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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Gua C, Liu Y, Liu Y, Lulla M, Marcotte D, Marx I, McDowell B, Mertsching E, Negrou E, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M. Hopkins BT, et al. Among authors: mcdowell b. Bioorg Med Chem. 2021 Aug 15;44:116275. doi: 10.1016/j.bmc.2021.116275. Epub 2021 Jun 15. Bioorg Med Chem. 2021. PMID: 34314938
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Marcotte D, McDowell B, Mertsching E, Negrou E, Otipoby KL, Poreci U, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M. Hopkins BT, et al. Among authors: mcdowell b. Bioorg Med Chem. 2019 Jul 1;27(13):2905-2913. doi: 10.1016/j.bmc.2019.05.021. Epub 2019 May 14. Bioorg Med Chem. 2019. PMID: 31138459
Drug discovery at signaling interfaces.
Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Wells J, et al. Among authors: mcdowell b. Ernst Schering Res Found Workshop. 2003;(42):19-27. doi: 10.1007/978-3-662-05314-0_3. Ernst Schering Res Found Workshop. 2003. PMID: 12664533 No abstract available.
The RESIST Study: Examining Cognitive Change in Rheumatoid Arthritis Patients with Mild Cognitive Impairment Being Treated with a TNF-Inhibitor Compared to a Conventional Synthetic Disease-Modifying Anti-Rheumatic Drug.
Marr C, McDowell B, Holmes C, Edwards CJ, Cardwell C, McHenry M, Meenagh G, Teeling JL, McGuinness B. Marr C, et al. Among authors: mcdowell b. J Alzheimers Dis. 2024;99(1):161-175. doi: 10.3233/JAD-231329. J Alzheimers Dis. 2024. PMID: 38669538
Society of Pediatric Nurses' Pre-Licensure Core Competencies Model, Second Edition.
Lewis MN, Goleman G, Kubin L, Alles K, Beam P, Benedetto CO, McDowell BM, Norman S, Stephen J, Wall C. Lewis MN, et al. Among authors: mcdowell bm. J Pediatr Nurs. 2024 May-Jun;76:207-209. doi: 10.1016/j.pedn.2024.03.032. Epub 2024 Apr 10. J Pediatr Nurs. 2024. PMID: 38604942 No abstract available.
Novel combinatorial autophagy inhibition therapy for triple negative breast cancers.
Abd El-Aziz YS, Toit-Thompson TD, McKay MJ, Molloy MP, Stoner S, McDowell B, Moon E, Sioson L, Sheen A, Chou A, Gill AJ, Jansson PJ, Sahni S. Abd El-Aziz YS, et al. Among authors: mcdowell b. Eur J Pharmacol. 2024 Jun 15;973:176568. doi: 10.1016/j.ejphar.2024.176568. Epub 2024 Apr 9. Eur J Pharmacol. 2024. PMID: 38604544 Free article.
Guideline-concordant breast cancer care by patient race and ethnicity accounting for individual-, facility- and area-level characteristics: a SEER-Medicare study.
Herbach EL, Curran M, Roberson ML, Carnahan RM, McDowell BD, Wang K, Lizarraga I, Nash SH, Charlton M. Herbach EL, et al. Among authors: mcdowell bd. Cancer Causes Control. 2024 Jul;35(7):1017-1031. doi: 10.1007/s10552-024-01859-3. Epub 2024 Mar 28. Cancer Causes Control. 2024. PMID: 38546924
193 results