Wang L - Search Results

1

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.

Xu J, Yu X, Martin TC, Bansal A, Cheung K, Lubin A, Stratikopoulos E, Cahuzac KM, Wang L, Xie L, Zhou R, Shen Y, Wu X, Yao S, Qiao R, Poulikakos PI, Chen X, Liu J, Jin J, Parsons R. Xu J, et al. Among authors: wang l. Cancer Discov. 2021 Dec 1;11(12):3064-3089. doi: 10.1158/2159-8290.CD-20-0815. Cancer Discov. 2021. PMID: 34301793 Free PMC article.

2

Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.

Yu X, Xu J, Xie L, Wang L, Shen Y, Cahuzac KM, Chen X, Liu J, Parsons RE, Jin J. Yu X, et al. Among authors: wang l. J Med Chem. 2021 Dec 23;64(24):18054-18081. doi: 10.1021/acs.jmedchem.1c01476. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34855399 Free PMC article.

3

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.

Wei J, Hu J, Wang L, Xie L, Jin MS, Chen X, Liu J, Jin J. Wei J, et al. Among authors: wang l. J Med Chem. 2019 Dec 12;62(23):10897-10911. doi: 10.1021/acs.jmedchem.9b01528. Epub 2019 Nov 27. J Med Chem. 2019. PMID: 31730343

4

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.

Cheng M, Yu X, Lu K, Xie L, Wang L, Meng F, Han X, Chen X, Liu J, Xiong Y, Jin J. Cheng M, et al. Among authors: wang l. J Med Chem. 2020 Feb 13;63(3):1216-1232. doi: 10.1021/acs.jmedchem.9b01566. Epub 2020 Jan 14. J Med Chem. 2020. PMID: 31895569 Free PMC article.

5

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.

Shen Y, Gao G, Yu X, Kim H, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Shen Y, et al. Among authors: wang l. J Med Chem. 2020 Sep 10;63(17):9977-9989. doi: 10.1021/acs.jmedchem.0c01111. Epub 2020 Aug 21. J Med Chem. 2020. PMID: 32787082 Free PMC article.

6

Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders.

Hu J, Wei J, Yim H, Wang L, Xie L, Jin MS, Kabir M, Qin L, Chen X, Liu J, Jin J. Hu J, et al. Among authors: wang l. J Med Chem. 2020 Dec 24;63(24):15883-15905. doi: 10.1021/acs.jmedchem.0c01609. Epub 2020 Dec 7. J Med Chem. 2020. PMID: 33284613 Free PMC article.

7

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders.

Wu X, Yang X, Xiong Y, Li R, Ito T, Ahmed TA, Karoulia Z, Adamopoulos C, Wang H, Wang L, Xie L, Liu J, Ueberheide B, Aaronson SA, Chen X, Buchanan SG, Sellers WR, Jin J, Poulikakos PI. Wu X, et al. Among authors: wang h, wang l. Nat Cancer. 2021 Apr;2(4):429-443. doi: 10.1038/s43018-021-00174-z. Epub 2021 Mar 1. Nat Cancer. 2021. PMID: 34568836 Free PMC article.

8

Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis.

Wang L, Wrobel JA, Xie L, Chen X. Wang L, et al. STAR Protoc. 2021 Feb 11;2(1):100338. doi: 10.1016/j.xpro.2021.100338. eCollection 2021 Mar 19. STAR Protoc. 2021. PMID: 33644773 Free PMC article.

9

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.

Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Wei J, et al. Among authors: wang l, wang gg. J Am Chem Soc. 2021 Sep 22;143(37):15073-15083. doi: 10.1021/jacs.1c04841. Epub 2021 Sep 14. J Am Chem Soc. 2021. PMID: 34520194 Free PMC article.

10

Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance.

Xie L, Liu C, Wang L, Gunawardena HP, Yu Y, Du R, Taxman DJ, Dai P, Yan Z, Yu J, Holly SP, Parise LV, Wan YY, Ting JP, Chen X. Xie L, et al. Among authors: wang l. Cell Rep. 2013 Mar 28;3(3):678-88. doi: 10.1016/j.celrep.2013.01.029. Epub 2013 Feb 21. Cell Rep. 2013. PMID: 23434512 Free PMC article.

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