Ratovitski T - Search Results

1

Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.

Akimov SS, Jiang M, Kedaigle AJ, Arbez N, Marque LO, Eddings CR, Ranum PT, Whelan E, Tang A, Wang R, DeVine LR, Talbot CC, Cole RN, Ratovitski T, Davidson BL, Fraenkel E, Ross CA. Akimov SS, et al. Among authors: ratovitski t. Hum Mol Genet. 2021 Nov 30;30(24):2469-2487. doi: 10.1093/hmg/ddab200. Hum Mol Genet. 2021. PMID: 34296279 Free PMC article.

2

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.

Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR. Schilling G, et al. Among authors: ratovitski t. Hum Mol Genet. 1999 Mar;8(3):397-407. doi: 10.1093/hmg/8.3.397. Hum Mol Genet. 1999. PMID: 9949199

3

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.

Ratovitski T, Nakamura M, D'Ambola J, Chighladze E, Liang Y, Wang W, Graham R, Hayden MR, Borchelt DR, Hirschhorn RR, Ross CA. Ratovitski T, et al. Cell Cycle. 2007 Dec 1;6(23):2970-81. doi: 10.4161/cc.6.23.4992. Cell Cycle. 2007. PMID: 18156806

4

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.

Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, D'Ambola J, Hou Z, Liang Y, Poirier MA, Hirschhorn RR, Graham R, Hayden MR, Cole RN, Ross CA. Ratovitski T, et al. J Biol Chem. 2009 Apr 17;284(16):10855-67. doi: 10.1074/jbc.M804813200. Epub 2009 Feb 9. J Biol Chem. 2009. PMID: 19204007 Free PMC article.

5

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.

Liang Y, Jiang H, Ratovitski T, Jie C, Nakamura M, Hirschhorn RR, Wang X, Smith WW, Hai T, Poirier MA, Ross CA. Liang Y, et al. Among authors: ratovitski t. Brain Res. 2009 Aug 25;1286:221-9. doi: 10.1016/j.brainres.2009.06.049. Epub 2009 Jun 24. Brain Res. 2009. PMID: 19559011 Free PMC article.

6

Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.

Ratovitski T, Chighladze E, Waldron E, Hirschhorn RR, Ross CA. Ratovitski T, et al. J Biol Chem. 2011 Apr 8;286(14):12578-89. doi: 10.1074/jbc.M110.185348. Epub 2011 Feb 10. J Biol Chem. 2011. PMID: 21310951 Free PMC article.

7

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.

Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA. Waldron-Roby E, et al. Among authors: ratovitski t. J Neurosci. 2012 Jan 4;32(1):183-93. doi: 10.1523/JNEUROSCI.1305-11.2012. J Neurosci. 2012. PMID: 22219281 Free PMC article.

8

Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.

Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA. Nucifora LG, et al. Among authors: ratovitski t. J Biol Chem. 2012 May 4;287(19):16017-28. doi: 10.1074/jbc.M111.252577. Epub 2012 Mar 20. J Biol Chem. 2012. PMID: 22433867 Free PMC article.

9

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

Ratovitski T, Chighladze E, Arbez N, Boronina T, Herbrich S, Cole RN, Ross CA. Ratovitski T, et al. Cell Cycle. 2012 May 15;11(10):2006-21. doi: 10.4161/cc.20423. Epub 2012 May 15. Cell Cycle. 2012. PMID: 22580459 Free PMC article.

10

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.

HD iPSC Consortium. HD iPSC Consortium. Cell Stem Cell. 2012 Aug 3;11(2):264-78. doi: 10.1016/j.stem.2012.04.027. Epub 2012 Jun 28. Cell Stem Cell. 2012. PMID: 22748968 Free PMC article.

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