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Page 1
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Imberdis T, et al. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20760-20769. doi: 10.1073/pnas.1903216116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548371 Free PMC article.
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Fanning S, et al. Among authors: imberdis t. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. Mol Cell. 2019. PMID: 30527540 Free PMC article.
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. Nuber S, et al. Among authors: imberdis t. Ann Neurol. 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23. Ann Neurol. 2021. PMID: 32996158 Free PMC article.
Low doses of bioherbicide favour prion aggregation and propagation in vivo.
Lafon PA, Imberdis T, Wang Y, Torrent J, Robitzer M, Huetter E, Alvarez-Martinez MT, Chevallier N, Givalois L, Desrumaux C, Liu J, Perrier V. Lafon PA, et al. Among authors: imberdis t. Sci Rep. 2018 May 23;8(1):8023. doi: 10.1038/s41598-018-25966-9. Sci Rep. 2018. PMID: 29795181 Free PMC article.
Identification of Anti-prion Compounds using a Novel Cellular Assay.
Imberdis T, Heeres JT, Yueh H, Fang C, Zhen J, Rich CB, Glicksman M, Beeler AB, Harris DA. Imberdis T, et al. J Biol Chem. 2016 Dec 9;291(50):26164-26176. doi: 10.1074/jbc.M116.745612. Epub 2016 Nov 1. J Biol Chem. 2016. PMID: 27803163 Free PMC article.
22 results