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Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
J Med Chem. 2021 Jul 22;64(14):9592-9638. doi: 10.1021/acs.jmedchem.1c00186. Epub 2021 Jul 12.
J Med Chem. 2021.
PMID: 34251209
Review.
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
Zaienne D, Willems S, Schierle S, Heering J, Merk D.
Zaienne D, et al.
J Med Chem. 2021 Oct 28;64(20):15126-15140. doi: 10.1021/acs.jmedchem.1c01077. Epub 2021 Oct 11.
J Med Chem. 2021.
PMID: 34633810
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Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists.
Zaienne D, Arifi S, Marschner JA, Heering J, Merk D.
Zaienne D, et al.
ChemMedChem. 2022 Aug 17;17(16):e202200259. doi: 10.1002/cmdc.202200259. Epub 2022 Jul 7.
ChemMedChem. 2022.
PMID: 35704774
Free PMC article.
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Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
Arifi S, Zaienne D, Heering J, Wein T, Zhubi R, Chaikuad A, Knapp S, Marschner JA, Merk D.
Arifi S, et al. Among authors: zaienne d.
Bioorg Chem. 2022 Dec;129:106164. doi: 10.1016/j.bioorg.2022.106164. Epub 2022 Sep 17.
Bioorg Chem. 2022.
PMID: 36162288
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Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.
Zaienne D, Isigkeit L, Marschner JA, Duensing-Kropp S, Höfner G, Merk D.
Zaienne D, et al.
ChemMedChem. 2023 Nov 2;18(21):e202300404. doi: 10.1002/cmdc.202300404. Epub 2023 Sep 25.
ChemMedChem. 2023.
PMID: 37697963
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Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Willems S, Busch R, Nawa F, Ballarotto M, Lillich FF, Kasch T, López-García Ú, Marschner JA, Rüger LA, Renelt B, Ohrndorf J, Arifi S, Zaienne D, Proschak E, Pabel J, Merk D.
Willems S, et al. Among authors: zaienne d.
J Med Chem. 2024 Aug 8;67(15):13324-13348. doi: 10.1021/acs.jmedchem.4c01218. Epub 2024 Jul 30.
J Med Chem. 2024.
PMID: 39081058
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