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Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Mathsyaraja H, Catchpole J, Freie B, Eastwood E, Babaeva E, Geuenich M, Cheng PF, Ayers J, Yu M, Wu N, Moorthi S, Poudel KR, Koehne A, Grady W, Houghton AM, Berger AH, Shiio Y, MacPherson D, Eisenman RN. Mathsyaraja H, et al. Among authors: macpherson d. Elife. 2021 Jul 8;10:e64212. doi: 10.7554/eLife.64212. Elife. 2021. PMID: 34236315 Free PMC article.
Lung Cancer Subtypes Generate Unique Immune Responses.
Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM. Busch SE, et al. Among authors: macpherson d. J Immunol. 2016 Dec 1;197(11):4493-4503. doi: 10.4049/jimmunol.1600576. Epub 2016 Oct 31. J Immunol. 2016. PMID: 27799309 Free PMC article.
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Jia D, et al. Among authors: macpherson d. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. Cancer Discov. 2018. PMID: 30181244 Free PMC article.
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Augert A, et al. Among authors: macpherson d. Sci Signal. 2019 Feb 5;12(567):eaau2922. doi: 10.1126/scisignal.aau2922. Sci Signal. 2019. PMID: 30723171 Free PMC article.
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. Augert A, et al. Among authors: macpherson d. Cancer Cell. 2020 Jul 13;38(1):97-114.e7. doi: 10.1016/j.ccell.2020.04.016. Epub 2020 May 28. Cancer Cell. 2020. PMID: 32470392 Free PMC article.
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, Leger P, Hiatt JB, Eastwood EC, Thomas R, Ibrahim AH, Jia D, Basom R, Eaton KD, Martins R, Houghton AM, MacPherson D. Grunblatt E, et al. Among authors: macpherson d. Genes Dev. 2020 Sep 1;34(17-18):1210-1226. doi: 10.1101/gad.340133.120. Epub 2020 Aug 20. Genes Dev. 2020. PMID: 32820040 Free PMC article.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Hiatt JB, et al. Among authors: macpherson d. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. Clin Cancer Res. 2022. PMID: 35920742 Free PMC article.
265 results