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Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Serrano-Maciá M, Simón J, González-Rellan MJ, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, De Urturi DS, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Gutiérrez de Juan V, Bizkarguenaga M, Fernández-Ramos D, Buque X, Baselli GA, Valenti LVC, Iruzubieta P, Crespo J, Villa E, Banales JM, Avila MA, Marin JJG, Aspichueta P, Sutherland J, Barrio R, Mayor U, Elortza F, Xirodimas DP, Nogueiras R, Delgado TC, Martínez-Chantar ML. Serrano-Maciá M, et al. Among authors: aspichueta p. Mol Metab. 2021 Nov;53:101275. doi: 10.1016/j.molmet.2021.101275. Epub 2021 Jun 18. Mol Metab. 2021. PMID: 34153521 Free PMC article.
[Molecular basis of obesity-related hepatic steatosis].
Buqué X, Aspichueta P, Ochoa B. Buqué X, et al. Among authors: aspichueta p. Rev Esp Enferm Dig. 2008 Sep;100(9):565-78. doi: 10.4321/s1130-01082008000900007. Rev Esp Enferm Dig. 2008. PMID: 19025308 Free article. Spanish.
Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.
Miquilena-Colina ME, Lima-Cabello E, Sánchez-Campos S, García-Mediavilla MV, Fernández-Bermejo M, Lozano-Rodríguez T, Vargas-Castrillón J, Buqué X, Ochoa B, Aspichueta P, González-Gallego J, García-Monzón C. Miquilena-Colina ME, et al. Among authors: aspichueta p. Gut. 2011 Oct;60(10):1394-402. doi: 10.1136/gut.2010.222844. Epub 2011 Jan 26. Gut. 2011. PMID: 21270117
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. Martínez-López N, et al. Among authors: aspichueta p. Gastroenterology. 2012 Sep;143(3):787-798.e13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8. Gastroenterology. 2012. PMID: 22687285 Free PMC article.
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.
Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Le Marchand-Brustel Y, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM. Vazquez-Chantada M, et al. Among authors: aspichueta p. Hepatology. 2013 Feb;57(2):505-14. doi: 10.1002/hep.26052. Epub 2012 Nov 27. Hepatology. 2013. PMID: 22961556
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