Hong Y - Search Results

1

Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor.

Chacko SA, Yang W, Wang Y, Tian Y, Hong Y, Wallace M, Wang B, Ewing WR, Luettgen JM, Shu YZ, Christopher LJ. Chacko SA, et al. Among authors: hong y. Xenobiotica. 2021 Aug;51(8):933-948. doi: 10.1080/00498254.2021.1943565. Epub 2021 Jul 5. Xenobiotica. 2021. PMID: 34151691

2

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.

Li W, Zhao W, Liu X, Huang X, Lopez OD, Leet JE, Fancher RM, Nguyen V, Goodrich J, Easter J, Hong Y, Caceres-Cortes J, Chang SY, Ma L, Belema M, Hamann LG, Gao M, Zhu M, Shu YZ, Humphreys WG, Johnson BM. Li W, et al. Among authors: hong y. Drug Metab Dispos. 2016 Jun;44(6):809-20. doi: 10.1124/dmd.115.068866. Epub 2016 Mar 30. Drug Metab Dispos. 2016. PMID: 27029743

3

Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.

Hong H, Caceres-Cortes J, Su H, Huang X, Roongta V, Bonacorsi S Jr, Hong Y, Tian Y, Iyer RA, Humphreys WG, Christopher LJ. Hong H, et al. Among authors: hong y. Chem Res Toxicol. 2011 Jan 14;24(1):125-34. doi: 10.1021/tx100337s. Epub 2010 Nov 16. Chem Res Toxicol. 2011. PMID: 21080678

4

Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

Yang Y, Miller KJ, Zhu Y, Hong Y, Tian Y, Murugesan N, Gu Z, O'Tanyi E, Keim WJ, Rohrbach KW, Johnghar S, Behnia K, Pelleymounter MA, Carlson KE, Ewing WR. Yang Y, et al. Among authors: hong y. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6856-60. doi: 10.1016/j.bmcl.2011.09.016. Epub 2011 Sep 13. Bioorg Med Chem Lett. 2011. PMID: 21962575

5

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

Jurica EA, Wu X, Williams KN, Hernandez AS, Nirschl DS, Rampulla RA, Mathur A, Zhou M, Cao G, Xie C, Jacob B, Cai H, Wang T, Murphy BJ, Liu H, Xu C, Kunselman LK, Hicks MB, Sun Q, Schnur DM, Sitkoff DF, Dierks EA, Apedo A, Moore DB, Foster KA, Cvijic ME, Panemangalore R, Flynn NA, Maxwell BD, Hong Y, Tian Y, Wilkes JJ, Zinker BA, Whaley JM, Barrish JC, Robl JA, Ewing WR, Ellsworth BA. Jurica EA, et al. Among authors: hong y. J Med Chem. 2017 Feb 23;60(4):1417-1431. doi: 10.1021/acs.jmedchem.6b01559. Epub 2017 Feb 9. J Med Chem. 2017. PMID: 28112924

6

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Gu X, Wang L, Gan J, Fancher RM, Tian Y, Hong Y, Lai Y, Sinz M, Shen H. Gu X, et al. Among authors: hong y. Drug Metab Dispos. 2020 Aug;48(8):724-734. doi: 10.1124/dmd.120.090670. Epub 2020 Jun 1. Drug Metab Dispos. 2020. PMID: 32482623

7

Synthesis and characterization of tritium labeled N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-sulfamoylbenzamide.

Hong Y, Hynes J, Tian Y, Balasubramanian B, Bonacorsi S Jr. Hong Y, et al. J Labelled Comp Radiopharm. 2015 Aug;58(10):414-8. doi: 10.1002/jlcr.3320. Epub 2015 Jul 31. J Labelled Comp Radiopharm. 2015. PMID: 26228905

8

Synthesis of tritium labeled 30-KDa PEG and conjugation to form [³ H]Pegbelfermin.

Easter JA, Tian Y, Burrell RC, Hong Y, Bonacorsi SJ Jr. Easter JA, et al. Among authors: hong y. J Labelled Comp Radiopharm. 2021 Oct;64(12):477-481. doi: 10.1002/jlcr.3940. Epub 2021 Aug 23. J Labelled Comp Radiopharm. 2021. PMID: 34386991

9

Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters.

Han YH, Busler D, Hong Y, Tian Y, Chen C, Rodrigues AD. Han YH, et al. Among authors: hong y. Drug Metab Dispos. 2010 Jul;38(7):1072-82. doi: 10.1124/dmd.109.031518. Epub 2010 Apr 1. Drug Metab Dispos. 2010. PMID: 20360302

10

Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human kidney drug transporters.

Han YH, Busler D, Hong Y, Tian Y, Chen C, Rodrigues AD. Han YH, et al. Among authors: hong y. Drug Metab Dispos. 2010 Jul;38(7):1064-71. doi: 10.1124/dmd.109.031526. Epub 2010 Apr 1. Drug Metab Dispos. 2010. PMID: 20360303

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