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Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S. Pujols J, et al. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. doi: 10.1073/pnas.1804198115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249646 Free PMC article.
Chemical Chaperones as Novel Drugs for Parkinson's Disease.
Pujols J, Peña-Díaz S, Pallarès I, Ventura S. Pujols J, et al. Trends Mol Med. 2020 Apr;26(4):408-421. doi: 10.1016/j.molmed.2020.01.005. Epub 2020 Feb 12. Trends Mol Med. 2020. PMID: 32277934 Review.
26 results