Wang D - Search Results

1

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.

Wang D, Ma J, Botuyan MV, Cui G, Yan Y, Ding D, Zhou Y, Krueger EW, Pei J, Wu X, Wang L, Pei H, McNiven MA, Ye D, Mer G, Huang H. Wang D, et al. Among authors: wang l. Sci Adv. 2021 Jun 18;7(25):eabd9208. doi: 10.1126/sciadv.abd9208. Print 2021 Jun. Sci Adv. 2021. PMID: 34144977 Free PMC article.

2

SPOP mutation induces DNA methylation via stabilizing GLP/G9a.

Zhang J, Gao K, Xie H, Wang D, Zhang P, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H. Zhang J, et al. Among authors: wang l, wang y, wang d, wang c. Nat Commun. 2021 Sep 29;12(1):5716. doi: 10.1038/s41467-021-25951-3. Nat Commun. 2021. PMID: 34588438 Free PMC article.

3

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.

Jin X, Yan Y, Wang D, Ding D, Ma T, Ye Z, Jimenez R, Wang L, Wu H, Huang H. Jin X, et al. Among authors: wang l, wang d. Mol Cell. 2018 Aug 16;71(4):592-605.e4. doi: 10.1016/j.molcel.2018.06.036. Epub 2018 Jul 26. Mol Cell. 2018. PMID: 30057199 Free PMC article.

4

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.

Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, Collins CC, Ye D, Wang Y, Huang H. Yan Y, et al. Among authors: wang y, wang d, wang s. EMBO Mol Med. 2019 Nov 7;11(11):e10659. doi: 10.15252/emmm.201910659. Epub 2019 Sep 26. EMBO Mol Med. 2019. PMID: 31559706 Free PMC article.

5

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG.

Shao J, Yan Y, Ding D, Wang D, He Y, Pan Y, Yan W, Kharbanda A, Li HY, Huang H. Shao J, et al. Among authors: wang d. Adv Sci (Weinh). 2021 Oct;8(20):e2102555. doi: 10.1002/advs.202102555. Epub 2021 Aug 16. Adv Sci (Weinh). 2021. PMID: 34397171 Free PMC article.

6

DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1.

Hong Z, Zhang W, Ding D, Huang Z, Yan Y, Cao W, Pan Y, Hou X, Weroha SJ, Karnes RJ, Wang D, Wu Q, Wu D, Huang H. Hong Z, et al. Among authors: wang d. Mol Cell. 2020 Sep 17;79(6):1008-1023.e4. doi: 10.1016/j.molcel.2020.07.028. Epub 2020 Aug 31. Mol Cell. 2020. PMID: 32871104 Free article.

7

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H. Zhang P, et al. Among authors: wang l, wang y, wang d, wang s, wang c. Nat Med. 2017 Sep;23(9):1055-1062. doi: 10.1038/nm.4379. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805822 Free PMC article.

8

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.

Yan Y, An J, Yang Y, Wu D, Bai Y, Cao W, Ma L, Chen J, Yu Z, He Y, Jin X, Pan Y, Ma T, Wang S, Hou X, Weroha SJ, Karnes RJ, Zhang J, Westendorf JJ, Wang L, Chen Y, Xu W, Zhu R, Wang D, Huang H. Yan Y, et al. Among authors: wang l, wang d, wang s. EMBO Mol Med. 2018 Apr;10(4):e8478. doi: 10.15252/emmm.201708478. EMBO Mol Med. 2018. PMID: 29523594 Free PMC article.

9

ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.

Tang B, Sun R, Wang D, Sheng H, Wei T, Wang L, Zhang J, Ho TH, Yang L, Wei Q, Huang H. Tang B, et al. Among authors: wang l, wang d. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2019052118. doi: 10.1073/pnas.2019052118. Proc Natl Acad Sci U S A. 2021. PMID: 33593912 Free PMC article.

10

An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.

Wu D, Yan Y, Wei T, Ye Z, Xiao Y, Pan Y, Orme JJ, Wang D, Wang L, Ren S, Huang H. Wu D, et al. Among authors: wang l, wang d. Cell Rep. 2021 Feb 16;34(7):108744. doi: 10.1016/j.celrep.2021.108744. Cell Rep. 2021. PMID: 33596421 Free article.

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