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Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E, Liu X, Zhan P. Kang D, et al. Among authors: arnold e. J Med Chem. 2020 Feb 13;63(3):1298-1312. doi: 10.1021/acs.jmedchem.9b01769. Epub 2020 Jan 24. J Med Chem. 2020. PMID: 31935327 Free PMC article.
Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first six months of the COVID-19 pandemic.
Lubin JH, Zardecki C, Dolan EM, Lu C, Shen Z, Dutta S, Westbrook JD, Hudson BP, Goodsell DS, Williams JK, Voigt M, Sarma V, Xie L, Venkatachalam T, Arnold S, Alvarado LHA, Catalfano K, Khan A, McCarthy E, Staggers S, Tinsley B, Trudeau A, Singh J, Whitmore L, Zheng H, Benedek M, Currier J, Dresel M, Duvvuru A, Dyszel B, Fingar E, Hennen EM, Kirsch M, Khan AA, Labrie-Cleary C, Laporte S, Lenkeit E, Martin K, Orellana M, de la Campa MO, Paredes I, Wheeler B, Rupert A, Sam A, See K, Zapata SS, Craig PA, Hall BL, Jiang J, Koeppe JR, Mills SA, Pikaart MJ, Roberts R, Bromberg Y, Hoyer JS, Duffy S, Tischfield J, Ruiz FX, Arnold E, Baum J, Sandberg J, Brannigan G, Khare SD, Burley SK. Lubin JH, et al. Among authors: arnold s, arnold e. bioRxiv [Preprint]. 2020 Dec 7:2020.12.01.406637. doi: 10.1101/2020.12.01.406637. bioRxiv. 2020. Update in: Proteins. 2022 May;90(5):1054-1080. doi: 10.1002/prot.26250 PMID: 33299989 Free PMC article. Updated. Preprint.
Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics.
Courouble VV, Dey SK, Yadav R, Timm J, Harrison JJEK, Ruiz FX, Arnold E, Griffin PR. Courouble VV, et al. Among authors: arnold e. bioRxiv [Preprint]. 2021 Mar 6:2021.03.06.434214. doi: 10.1101/2021.03.06.434214. bioRxiv. 2021. Update in: J Am Soc Mass Spectrom. 2021 Jul 7;32(7):1618-1630. doi: 10.1021/jasms.1c00086 PMID: 33688660 Free PMC article. Updated. Preprint.
949 results