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Assessment of the rules related to gaining activity against Gram-negative bacteria.
Ropponen HK, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch AKH. Ropponen HK, et al. Among authors: rottmann m. RSC Med Chem. 2021 Mar 3;12(4):593-601. doi: 10.1039/d0md00409j. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046630 Free PMC article.
Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD.
Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Höffken HW, Seet M, Eisenreich W, Knölker HJ, Fischer M, Bacher A, Groll M, Diederich F. Kunfermann A, et al. Among authors: rottmann m. Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2235-9. doi: 10.1002/anie.201309557. Epub 2014 Jan 20. Angew Chem Int Ed Engl. 2014. PMID: 24446431
Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.
Reker D, Seet M, Pillong M, Koch CP, Schneider P, Witschel MC, Rottmann M, Freymond C, Brun R, Schweizer B, Illarionov B, Bacher A, Fischer M, Diederich F, Schneider G. Reker D, et al. Among authors: rottmann m. Angew Chem Int Ed Engl. 2014 Jul 1;53(27):7079-84. doi: 10.1002/anie.201311162. Epub 2014 Jun 4. Angew Chem Int Ed Engl. 2014. PMID: 24895172
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.
Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F. Witschel MC, et al. Among authors: rottmann m. J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18. J Med Chem. 2015. PMID: 25785478
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures.
Schwertz G, Witschel MC, Rottmann M, Bonnert R, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Ittarat W, Schäfer A, Aponte RA, Charman SA, White KL, Kundu A, Sadhukhan S, Lloyd M, Freiberg GM, Srikumaran M, Siggel M, Zwyssig A, Chaiyen P, Diederich F. Schwertz G, et al. Among authors: rottmann m. J Med Chem. 2017 Jun 22;60(12):4840-4860. doi: 10.1021/acs.jmedchem.7b00008. Epub 2017 Jun 13. J Med Chem. 2017. PMID: 28537728
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs.
Schwertz G, Frei MS, Witschel MC, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Ittarat W, Schäfer A, Aponte RA, Trapp N, Mark K, Chaiyen P, Diederich F. Schwertz G, et al. Among authors: rottmann m. Chemistry. 2017 Oct 12;23(57):14345-14357. doi: 10.1002/chem.201703244. Epub 2017 Oct 2. Chemistry. 2017. PMID: 28967982
134 results