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Page 1
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Dubiella C, Pinch BJ, Koikawa K, Zaidman D, Poon E, Manz TD, Nabet B, He S, Resnick E, Rogel A, Langer EM, Daniel CJ, Seo HS, Chen Y, Adelmant G, Sharifzadeh S, Ficarro SB, Jamin Y, Martins da Costa B, Zimmerman MW, Lian X, Kibe S, Kozono S, Doctor ZM, Browne CM, Yang A, Stoler-Barak L, Shah RB, Vangos NE, Geffken EA, Oren R, Koide E, Sidi S, Shulman Z, Wang C, Marto JA, Dhe-Paganon S, Look T, Zhou XZ, Lu KP, Sears RC, Chesler L, Gray NS, London N. Dubiella C, et al. Among authors: kibe s. Nat Chem Biol. 2021 Sep;17(9):954-963. doi: 10.1038/s41589-021-00786-7. Epub 2021 May 10. Nat Chem Biol. 2021. PMID: 33972797 Free PMC article.
Identification of a potent and selective covalent Pin1 inhibitor.
Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Pinch BJ, et al. Among authors: kibe s. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483379 Free PMC article.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Koikawa K, et al. Among authors: kibe s. Cell. 2021 Sep 2;184(18):4753-4771.e27. doi: 10.1016/j.cell.2021.07.020. Epub 2021 Aug 12. Cell. 2021. PMID: 34388391 Free PMC article.
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
Yan Z, Ohuchida K, Fei S, Zheng B, Guan W, Feng H, Kibe S, Ando Y, Koikawa K, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Hashizume M, Nakamura M. Yan Z, et al. Among authors: kibe s. J Exp Clin Cancer Res. 2019 May 27;38(1):221. doi: 10.1186/s13046-019-1226-8. J Exp Clin Cancer Res. 2019. PMID: 31133044 Free PMC article.
Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion.
Kibe S, Ohuchida K, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Okumura T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Shimamoto M, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M. Kibe S, et al. Cancer Lett. 2019 Mar 1;444:70-81. doi: 10.1016/j.canlet.2018.12.005. Epub 2018 Dec 24. Cancer Lett. 2019. PMID: 30590101 Free article.
S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer.
Nakayama H, Ohuchida K, Yonenaga A, Sagara A, Ando Y, Kibe S, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Shido K, Miyoshi K, Nakata K, Moriyama T, Miyasaka Y, Inoue S, Ohtsuka T, Mizumoto K, Nakamura M. Nakayama H, et al. Among authors: kibe s. Int J Oncol. 2019 Jul;55(1):211-222. doi: 10.3892/ijo.2019.4812. Epub 2019 May 24. Int J Oncol. 2019. PMID: 31180531
Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix.
Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Okumura T, et al. Among authors: kibe s. Int J Cancer. 2019 Mar 15;144(6):1401-1413. doi: 10.1002/ijc.31775. Epub 2018 Oct 10. Int J Cancer. 2019. PMID: 30152542
Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Koikawa K, et al. Among authors: kibe s. Cancer Lett. 2018 Jan 1;412:143-154. doi: 10.1016/j.canlet.2017.10.010. Epub 2017 Oct 20. Cancer Lett. 2018. PMID: 29061505
Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma.
Koikawa K, Ohuchida K, Ando Y, Kibe S, Nakayama H, Takesue S, Endo S, Abe T, Okumura T, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Koikawa K, et al. Among authors: kibe s. Cancer Lett. 2018 Jul 1;425:65-77. doi: 10.1016/j.canlet.2018.03.031. Epub 2018 Mar 23. Cancer Lett. 2018. PMID: 29580808
31 results