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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress.
Sipol A, Hameister E, Xue B, Hofstetter J, Barenboim M, Öllinger R, Jain G, Prexler C, Rubio RA, Baldauf MC, Franchina DG, Petry A, Schmäh J, Thiel U, Görlach A, Cario G, Brenner D, Richter GHS, Grünewald TGP, Rad R, Wolf E, Ruland J, Sorensen PH, Burdach SEG. Sipol A, et al. Among authors: brenner d. Blood. 2022 Feb 24;139(8):1184-1197. doi: 10.1182/blood.2020007932. Blood. 2022. PMID: 33908607 Free PMC article.
Survival of the fittest: Cancer challenges T cell metabolism.
Franchina DG, He F, Brenner D. Franchina DG, et al. Among authors: brenner d. Cancer Lett. 2018 Jan 1;412:216-223. doi: 10.1016/j.canlet.2017.10.014. Epub 2017 Oct 24. Cancer Lett. 2018. PMID: 29074426 Review.
B-Cell Metabolic Remodeling and Cancer.
Franchina DG, Grusdat M, Brenner D. Franchina DG, et al. Among authors: brenner d. Trends Cancer. 2018 Feb;4(2):138-150. doi: 10.1016/j.trecan.2017.12.006. Epub 2018 Feb 1. Trends Cancer. 2018. PMID: 29458963 Review.
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D. Kurniawan H, et al. Among authors: brenner d. Cell Metab. 2020 May 5;31(5):920-936.e7. doi: 10.1016/j.cmet.2020.03.004. Epub 2020 Mar 25. Cell Metab. 2020. PMID: 32213345 Free PMC article.
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.
Franchina DG, Kurniawan H, Grusdat M, Binsfeld C, Guerra L, Bonetti L, Soriano-Baguet L, Ewen A, Kobayashi T, Farinelle S, Minafra AR, Vandamme N, Carpentier A, Borgmann FK, Jäger C, Chen Y, Kleinewietfeld M, Vasiliou V, Mittelbronn M, Hiller K, Lang PA, Brenner D. Franchina DG, et al. Among authors: brenner d. Nat Commun. 2022 Apr 4;13(1):1789. doi: 10.1038/s41467-022-29426-x. Nat Commun. 2022. PMID: 35379825 Free PMC article.
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing.
Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ. Danileviciute E, et al. Among authors: brenner d. Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. Nat Metab. 2022. PMID: 35618940
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Grusdat M, Spath S, Koncina E, Ewen A, Binsfeld C, Verschueren C, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Among authors: brenner d. bioRxiv [Preprint]. 2023 Jul 7:2023.07.06.547932. doi: 10.1101/2023.07.06.547932. bioRxiv. 2023. Update in: Cell Metab. 2024 Aug 6;36(8):1726-1744.e10. doi: 10.1016/j.cmet.2024.06.010. PMID: 37489135 Free PMC article. Updated. Preprint.
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FHA, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland J. Wartewig T, et al. Among authors: brenner d. Nat Cancer. 2023 Oct;4(10):1508-1525. doi: 10.1038/s43018-023-00635-7. Epub 2023 Sep 18. Nat Cancer. 2023. PMID: 37723306 Free PMC article.
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan YT, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Among authors: brenner d. Cell Metab. 2024 Aug 6;36(8):1726-1744.e10. doi: 10.1016/j.cmet.2024.06.010. Epub 2024 Jul 9. Cell Metab. 2024. PMID: 38986617 Free article.
2,050 results