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Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F; QCRG Structural Biology Consortium; Kumar GR, Ott M, Baker D, El-Samad H. Weinberg ZY, et al. Among authors: cao l. bioRxiv [Preprint]. 2021 Apr 20:2021.04.20.440678. doi: 10.1101/2021.04.20.440678. bioRxiv. 2021. PMID: 33907743 Free PMC article. Preprint.
De novo design of modular and tunable allosteric biosensors.
Quijano-Rubio A, Yeh HW, Park J, Lee H, Langan RA, Boyken SE, Lajoie MJ, Cao L, Chow CM, Miranda MC, Wi J, Hong HJ, Stewart L, Oh BH, Baker D. Quijano-Rubio A, et al. Among authors: cao l. bioRxiv [Preprint]. 2020 Jul 20:2020.07.18.206946. doi: 10.1101/2020.07.18.206946. bioRxiv. 2020. Update in: Nature. 2021 Mar;591(7850):482-487. doi: 10.1038/s41586-021-03258-z. PMID: 32743576 Free PMC article. Updated. Preprint.
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. Cao L, et al. Science. 2020 Oct 23;370(6515):426-431. doi: 10.1126/science.abd9909. Epub 2020 Sep 9. Science. 2020. PMID: 32907861 Free PMC article.
De novo design of modular and tunable protein biosensors.
Quijano-Rubio A, Yeh HW, Park J, Lee H, Langan RA, Boyken SE, Lajoie MJ, Cao L, Chow CM, Miranda MC, Wi J, Hong HJ, Stewart L, Oh BH, Baker D. Quijano-Rubio A, et al. Among authors: cao l. Nature. 2021 Mar;591(7850):482-487. doi: 10.1038/s41586-021-03258-z. Epub 2021 Jan 27. Nature. 2021. PMID: 33503651 Free PMC article.
Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice.
Case JB, Chen RE, Cao L, Ying B, Winkler ES, Goreshnik I, Shrihari S, Kafai NM, Bailey AL, Xie X, Shi PY, Ravichandran R, Carter L, Stewart L, Baker D, Diamond MS. Case JB, et al. Among authors: cao l. bioRxiv [Preprint]. 2021 Mar 1:2021.03.01.433110. doi: 10.1101/2021.03.01.433110. bioRxiv. 2021. Update in: Cell Host Microbe. 2021 Jul 14;29(7):1151-1161.e5. doi: 10.1016/j.chom.2021.06.008. PMID: 33688650 Free PMC article. Updated. Preprint.
Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease.
Case JB, Chen RE, Cao L, Ying B, Winkler ES, Johnson M, Goreshnik I, Pham MN, Shrihari S, Kafai NM, Bailey AL, Xie X, Shi PY, Ravichandran R, Carter L, Stewart L, Baker D, Diamond MS. Case JB, et al. Among authors: cao l. Cell Host Microbe. 2021 Jul 14;29(7):1151-1161.e5. doi: 10.1016/j.chom.2021.06.008. Epub 2021 Jun 24. Cell Host Microbe. 2021. PMID: 34192518 Free PMC article.
Multivalent designed proteins protect against SARS-CoV-2 variants of concern.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger-Gericke A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken S, Ljubetič A, Edman N, Ueda G, Chow C, Addetia A, Panpradist N, Gale M Jr, Freedman BS, Lutz BR, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: cao l. bioRxiv [Preprint]. 2021 Jul 7:2021.07.07.451375. doi: 10.1101/2021.07.07.451375. bioRxiv. 2021. Update in: Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. PMID: 34268509 Free PMC article. Updated. Preprint.
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: cao l. Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25. Sci Transl Med. 2022. PMID: 35412328 Free PMC article.
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