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Page 1
Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.
Smit FX, van der Velden WJC, Kizilkaya HS, Nørskov A, Lückmann M, Hansen TN, Sparre-Ulrich AH, Qvotrup K, Frimurer TM, Rosenkilde MM. Smit FX, et al. Structure. 2021 Jul 1;29(7):679-693.e6. doi: 10.1016/j.str.2021.04.001. Epub 2021 Apr 22. Structure. 2021. PMID: 33891864 Free article.
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.
van der Velden WJC, Smit FX, Christiansen CB, Møller TC, Hjortø GM, Larsen O, Schiellerup SP, Bräuner-Osborne H, Holst JJ, Hartmann B, Frimurer TM, Rosenkilde MM. van der Velden WJC, et al. Among authors: smit fx. ACS Pharmacol Transl Sci. 2021 Jan 19;4(1):296-313. doi: 10.1021/acsptsci.0c00193. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615180 Free PMC article.
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Gabe MBN, et al. Among authors: smit fx. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):122-132. doi: 10.1111/bcpt.13289. Epub 2019 Aug 19. Basic Clin Pharmacol Toxicol. 2020. PMID: 31299132 Free PMC article.