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Page 1
Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2.
Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP. Mast FD, et al. Among authors: chait bt. bioRxiv [Preprint]. 2021 Apr 10:2021.04.08.438911. doi: 10.1101/2021.04.08.438911. bioRxiv. 2021. Update in: Elife. 2021 Dec 07;10:e73027. doi: 10.7554/eLife.73027. PMID: 33851164 Free PMC article. Updated. Preprint.
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Malone B, Chen J, Wang Q, Llewellyn E, Choi YJ, Olinares PDB, Cao X, Hernandez C, Eng ET, Chait BT, Shaw DE, Landick R, Darst SA, Campbell EA. Malone B, et al. Among authors: chait bt. bioRxiv [Preprint]. 2021 Mar 14:2021.03.13.435256. doi: 10.1101/2021.03.13.435256. bioRxiv. 2021. Update in: Cell. 2020 Sep 17;182(6):1560-1573.e13. doi: 10.1016/j.cell.2020.07.033. Update in: Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2102516118. doi: 10.1073/pnas.2102516118. PMID: 33758867 Free PMC article. Updated. Preprint.
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
Taylor MS, Connie W, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cheng WC, Heaps J, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Norden BL, Chait BT, Goggins M, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Jung E, Arora KS, Zukerberg LR, Yilmaz OH, Chi G, Matulonis UA, Song Y, Nieman L, Parikh AR, Strickland M, Corcoran RB, Mustelin T, Eng G, Yilmaz ÃH, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH. Taylor MS, et al. Among authors: chait bt. bioRxiv [Preprint]. 2023 Mar 17:2023.01.25.525462. doi: 10.1101/2023.01.25.525462. bioRxiv. 2023. Update in: Cancer Discov. 2023 Dec 12;13(12):2532-2547. doi: 10.1158/2159-8290.CD-23-0313. PMID: 36747644 Free PMC article. Updated. Preprint.
Dynamic molecular mechanism of the nuclear pore complex permeability barrier.
Kozai T, Fernandez-Martinez J, van Eeuwen T, Gallardo P, Kapinos LE, Mazur A, Zhang W, Tempkin J, Panatala R, Delgado-Izquierdo M, Raveh B, Sali A, Chait BT, Veenhoff LM, Rout MP, Lim RYH. Kozai T, et al. Among authors: chait bt. bioRxiv [Preprint]. 2023 Apr 14:2023.03.31.535055. doi: 10.1101/2023.03.31.535055. bioRxiv. 2023. PMID: 37066338 Free PMC article. Preprint.
Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus.
Ketaren NE, Mast FD, Fridy PC, Olivier JP, Sanyal T, Sali A, Chait BT, Rout MP, Aitchison JD. Ketaren NE, et al. Among authors: chait bt. bioRxiv [Preprint]. 2024 Jan 29:2023.07.14.549041. doi: 10.1101/2023.07.14.549041. bioRxiv. 2024. Update in: Elife. 2024 May 07;12:RP89423. doi: 10.7554/eLife.89423. PMID: 37503298 Free PMC article. Updated. Preprint.
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain.
Small GI, Fedorova O, Olinares PDB, Chandanani J, Banerjee A, Choi YJ, Molina H, Chait B, Darst SA, Campbell EA. Small GI, et al. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.558837. doi: 10.1101/2023.09.25.558837. bioRxiv. 2023. Update in: Mol Cell. 2023 Nov 2;83(21):3921-3930.e7. doi: 10.1016/j.molcel.2023.10.001. PMID: 37808858 Free PMC article. Updated. Preprint.
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: chait bt. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391. bioRxiv. 2023. Update in: J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. PMID: 37808863 Free PMC article. Updated. Preprint.
The molecular architecture of the nuclear basket.
Singh D, Soni N, Hutchings J, Echeverria I, Shaikh F, Duquette M, Suslov S, Li Z, van Eeuwen T, Molloy K, Shi Y, Wang J, Guo Q, Chait BT, Fernandez-Martinez J, Rout MP, Sali A, Villa E. Singh D, et al. Among authors: chait bt. Cell. 2024 Sep 19;187(19):5267-5281.e13. doi: 10.1016/j.cell.2024.07.020. Epub 2024 Aug 9. Cell. 2024. PMID: 39127037 Free PMC article.
390 results