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A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.
Yi Y, Li Y, Meng Q, Li Q, Li F, Lu B, Shen J, Fazli L, Zhao D, Li C, Jiang W, Wang R, Liu Q, Szczepanski A, Li Q, Qin W, Weiner AB, Lotan TL, Ji Z, Kalantry S, Wang L, Schaeffer EM, Niu H, Dong X, Zhao W, Chen K, Cao Q. Yi Y, et al. Among authors: chen k. Nat Cell Biol. 2021 Apr;23(4):341-354. doi: 10.1038/s41556-021-00653-6. Epub 2021 Apr 1. Nat Cell Biol. 2021. PMID: 33795875 Free PMC article.
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. Dhar SS, et al. Among authors: chen k. Mol Cell. 2018 Jun 7;70(5):825-841.e6. doi: 10.1016/j.molcel.2018.04.028. Epub 2018 May 31. Mol Cell. 2018. PMID: 29861161 Free PMC article.
Machine learning uncovers cell identity regulator by histone code.
Xia B, Zhao D, Wang G, Zhang M, Lv J, Tomoiaga AS, Li Y, Wang X, Meng S, Cooke JP, Cao Q, Zhang L, Chen K. Xia B, et al. Among authors: chen k. Nat Commun. 2020 Jun 1;11(1):2696. doi: 10.1038/s41467-020-16539-4. Nat Commun. 2020. PMID: 32483223 Free PMC article.
Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2.
Li Q, Liu KY, Liu Q, Wang G, Jiang W, Meng Q, Yi Y, Yang Y, Wang R, Zhu S, Li C, Wu L, Zhao D, Yan L, Zhang L, Kim JS, Zu X, Kozielski AJ, Qian W, Chang JC, Patnaik A, Chen K, Cao Q. Li Q, et al. Among authors: chen k. Mol Cancer Ther. 2020 Oct;19(10):2023-2033. doi: 10.1158/1535-7163.MCT-20-0250. Epub 2020 Aug 27. Mol Cancer Ther. 2020. PMID: 32855270 Free PMC article.
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