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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Abdel-Halim M, Sigler S, Racheed NAS, Hefnawy A, Fathalla RK, Hammam MA, Maher A, Maxuitenko Y, Keeton AB, Hartmann RW, Engel M, Piazza GA, Abadi AH. Abdel-Halim M, et al. Among authors: sigler s. J Med Chem. 2021 Apr 22;64(8):4462-4477. doi: 10.1021/acs.jmedchem.0c01120. Epub 2021 Apr 1. J Med Chem. 2021. PMID: 33793216
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA. Li N, et al. Among authors: sigler s. Oncogene. 2015 Mar 19;34(12):1499-509. doi: 10.1038/onc.2014.94. Epub 2014 Apr 7. Oncogene. 2015. PMID: 24704829 Free PMC article.
Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription.
Sigler S, Abdel-Halim M, Fathalla RK, Da Silva LM, Keeton AB, Maxuitenko YY, Berry K, Zhou G, Engel M, Abadi AH, Piazza GA. Sigler S, et al. Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353. Online ahead of print. Anticancer Agents Med Chem. 2024. PMID: 39225209
Transport Rates and Prehospital Intervals for an EMS Telemedicine Intervention.
Varughese R, Cater-Cyker M, Sabbineni R, Sigler S, Champoux S, Gamber M, Burnett SJ, Troutman G, Chuang C, Sanders R, Doran J, Nataneli N, Cooney DR, Bloomstone JA, Clemency BM. Varughese R, et al. Among authors: sigler s. Prehosp Emerg Care. 2024;28(5):706-711. doi: 10.1080/10903127.2023.2266023. Epub 2023 Oct 27. Prehosp Emerg Care. 2024. PMID: 37800855
Site-based data curation based on hot spring geobiology.
Palmer CL, Thomer AK, Baker KS, Wickett KM, Hendrix CL, Rodman A, Sigler S, Fouke BW. Palmer CL, et al. Among authors: sigler s. PLoS One. 2017 Mar 2;12(3):e0172090. doi: 10.1371/journal.pone.0172090. eCollection 2017. PLoS One. 2017. PMID: 28253269 Free PMC article.
19 results