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Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Leskelä S, Huber N, Hoffmann D, Rostalski H, Remes AM, Takalo M, Hiltunen M, Haapasalo A. Leskelä S, et al. Among authors: hiltunen m. Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119021. doi: 10.1016/j.bbamcr.2021.119021. Epub 2021 Mar 26. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33775797 Free article.
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. Viswanathan J, et al. Among authors: hiltunen m. Traffic. 2011 Mar;12(3):330-48. doi: 10.1111/j.1600-0854.2010.01149.x. Epub 2011 Jan 7. Traffic. 2011. PMID: 21143716 Free PMC article.
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. Sarajärvi T, et al. Among authors: hiltunen m. Mol Cell Biol. 2011 Jun;31(11):2326-40. doi: 10.1128/MCB.05015-11. Epub 2011 Apr 4. Mol Cell Biol. 2011. PMID: 21464208 Free PMC article.
396 results