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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: cully sj. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
Expedient synthesis of an atypical oxazolidinone compound library.
Cully SJ, Storr TE, Rawling MJ, Abeysena IR, Hamza D, Jones G, Pearce CA, Quddus A, Lewis W, Stockman RA. Cully SJ, et al. Bioorg Med Chem. 2016 Nov 1;24(21):5249-5257. doi: 10.1016/j.bmc.2016.08.046. Epub 2016 Aug 27. Bioorg Med Chem. 2016. PMID: 27622748