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Page 1
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
Modeling water molecules in protein-ligand docking using GOLD.
Verdonk ML, Chessari G, Cole JC, Hartshorn MJ, Murray CW, Nissink JW, Taylor RD, Taylor R. Verdonk ML, et al. Among authors: chessari g. J Med Chem. 2005 Oct 6;48(20):6504-15. doi: 10.1021/jm050543p. J Med Chem. 2005. PMID: 16190776
Application of fragment screening by X-ray crystallography to beta-secretase.
Murray CW, Callaghan O, Chessari G, Cleasby A, Congreve M, Frederickson M, Hartshorn MJ, McMenamin R, Patel S, Wallis N. Murray CW, et al. Among authors: chessari g. J Med Chem. 2007 Mar 22;50(6):1116-23. doi: 10.1021/jm0611962. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315856
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G. Edwards PD, et al. Among authors: chessari g. J Med Chem. 2007 Nov 29;50(24):5912-25. doi: 10.1021/jm070829p. Epub 2007 Nov 7. J Med Chem. 2007. PMID: 17985862
Recent developments in fragment-based drug discovery.
Congreve M, Chessari G, Tisi D, Woodhead AJ. Congreve M, et al. Among authors: chessari g. J Med Chem. 2008 Jul 10;51(13):3661-80. doi: 10.1021/jm8000373. Epub 2008 May 6. J Med Chem. 2008. PMID: 18457385 Review. No abstract available.
45 results