Aichem A - Search Results

1

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy.

Roverato ND, Sailer C, Catone N, Aichem A, Stengel F, Groettrup M. Roverato ND, et al. Among authors: aichem a. Cell Rep. 2021 Mar 16;34(11):108857. doi: 10.1016/j.celrep.2021.108857. Cell Rep. 2021. PMID: 33730565 Free article.

2

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.

Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rani N, Schmidtke G, Groettrup M. Aichem A, et al. Nat Commun. 2010 May 4;1:13. doi: 10.1038/ncomms1012. Nat Commun. 2010. PMID: 20975683 Free article.

3

Detection and analysis of FAT10 modification.

Aichem A, Groettrup M. Aichem A, et al. Methods Mol Biol. 2012;832:125-32. doi: 10.1007/978-1-61779-474-2_7. Methods Mol Biol. 2012. PMID: 22350880

4

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.

Rani N, Aichem A, Schmidtke G, Kreft SG, Groettrup M. Rani N, et al. Among authors: aichem a. Nat Commun. 2012 Mar 20;3:749. doi: 10.1038/ncomms1752. Nat Commun. 2012. PMID: 22434192 Free article.

5

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.

Aichem A, Kalveram B, Spinnenhirn V, Kluge K, Catone N, Johansen T, Groettrup M. Aichem A, et al. J Cell Sci. 2012 Oct 1;125(Pt 19):4576-85. doi: 10.1242/jcs.107789. Epub 2012 Jul 13. J Cell Sci. 2012. PMID: 22797925

6

FAT10ylation as a signal for proteasomal degradation.

Schmidtke G, Aichem A, Groettrup M. Schmidtke G, et al. Among authors: aichem a. Biochim Biophys Acta. 2014 Jan;1843(1):97-102. doi: 10.1016/j.bbamcr.2013.01.009. Epub 2013 Jan 18. Biochim Biophys Acta. 2014. PMID: 23333871 Free article. Review.

7

Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.

Aichem A, Catone N, Groettrup M. Aichem A, et al. FEBS J. 2014 Apr;281(7):1848-59. doi: 10.1111/febs.12745. Epub 2014 Mar 3. FEBS J. 2014. PMID: 24528925 Free article.

8

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice.

Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M. Spinnenhirn V, et al. Among authors: aichem a. J Cell Sci. 2014 Nov 15;127(Pt 22):4883-93. doi: 10.1242/jcs.152371. Epub 2014 Sep 30. J Cell Sci. 2014. PMID: 25271057

9

Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.

Bialas J, Groettrup M, Aichem A. Bialas J, et al. Among authors: aichem a. PLoS One. 2015 Mar 13;10(3):e0120329. doi: 10.1371/journal.pone.0120329. eCollection 2015. PLoS One. 2015. PMID: 25768649 Free PMC article.

10

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.

Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP. Dufner A, et al. Among authors: aichem a. Nat Immunol. 2015 Sep;16(9):950-60. doi: 10.1038/ni.3230. Epub 2015 Jul 27. Nat Immunol. 2015. PMID: 26214742

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