Gooptu B - Search Results

1

Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.

Fromme M, Schneider CV, Pereira V, Hamesch K, Pons M, Reichert MC, Benini F, Ellis P, H Thorhauge K, Mandorfer M, Burbaum B, Woditsch V, Chorostowska-Wynimko J, Verbeek J, Nevens F, Genesca J, Miravitlles M, Nuñez A, Schaefer B, Zoller H, Janciauskiene S, Abreu N, Jasmins L, Gaspar R, Liberal R, Macedo G, Mahadeva R, Gomes C, Schneider KM, Trauner M, Krag A, Gooptu B, Thorburn D, Marshall A, Hurst JR, Lomas DA, Lammert F, Gaisa NT, Clark V, Griffiths W, Trautwein C, Turner AM, McElvaney NG, Strnad P. Fromme M, et al. Among authors: gooptu b. Gut. 2022 Feb;71(2):415-423. doi: 10.1136/gutjnl-2020-323729. Epub 2021 Feb 25. Gut. 2022. PMID: 33632708

2

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

Gooptu B, Hazes B, Chang WS, Dafforn TR, Carrell RW, Read RJ, Lomas DA. Gooptu B, et al. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):67-72. doi: 10.1073/pnas.97.1.67. Proc Natl Acad Sci U S A. 2000. PMID: 10618372 Free PMC article.

3

Nucleation of alpha 1-antichymotrypsin polymerization.

Crowther DC, Serpell LC, Dafforn TR, Gooptu B, Lomas DA. Crowther DC, et al. Among authors: gooptu b. Biochemistry. 2003 Mar 4;42(8):2355-63. doi: 10.1021/bi0259305. Biochemistry. 2003. PMID: 12600202

4

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.

Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA. Mallya M, et al. Among authors: gooptu b. J Med Chem. 2007 Nov 1;50(22):5357-63. doi: 10.1021/jm070687z. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918823 Free PMC article.

5

Polymers and inflammation: disease mechanisms of the serpinopathies.

Gooptu B, Lomas DA. Gooptu B, et al. J Exp Med. 2008 Jul 7;205(7):1529-34. doi: 10.1084/jem.20072080. J Exp Med. 2008. PMID: 18591408 Free PMC article. Review.

6

Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design.

Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE. Gooptu B, et al. J Mol Biol. 2009 Apr 10;387(4):857-68. doi: 10.1016/j.jmb.2009.01.069. Epub 2009 Feb 14. J Mol Biol. 2009. PMID: 19232354 Free PMC article.

7

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.

Gooptu B, Lomas DA. Gooptu B, et al. Annu Rev Biochem. 2009;78:147-76. doi: 10.1146/annurev.biochem.78.082107.133320. Annu Rev Biochem. 2009. PMID: 19245336 Review.

8

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.

Ekeowa UI, Gooptu B, Belorgey D, Hägglöf P, Karlsson-Li S, Miranda E, Pérez J, MacLeod I, Kroger H, Marciniak SJ, Crowther DC, Lomas DA. Ekeowa UI, et al. Among authors: gooptu b. Clin Sci (Lond). 2009 May 14;116(12):837-50. doi: 10.1042/CS20080484. Clin Sci (Lond). 2009. PMID: 19426146 Review.

9

Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights.

Gooptu B, Ekeowa UI, Lomas DA. Gooptu B, et al. Eur Respir J. 2009 Aug;34(2):475-88. doi: 10.1183/09031936.00096508. Eur Respir J. 2009. PMID: 19648523 Free article. Review.

10

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA. Miranda E, et al. Among authors: gooptu b. Hepatology. 2010 Sep;52(3):1078-88. doi: 10.1002/hep.23760. Hepatology. 2010. PMID: 20583215

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