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Approaching infinite affinity through engineering of peptide-protein interaction.
Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP, Howarth M. Keeble AH, et al. Among authors: howarth m. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26523-26533. doi: 10.1073/pnas.1909653116. Epub 2019 Dec 10. Proc Natl Acad Sci U S A. 2019. PMID: 31822621 Free PMC article.
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.
Tan TK, Rijal P, Rahikainen R, Keeble AH, Schimanski L, Hussain S, Harvey R, Hayes JWP, Edwards JC, McLean RK, Martini V, Pedrera M, Thakur N, Conceicao C, Dietrich I, Shelton H, Ludi A, Wilsden G, Browning C, Zagrajek AK, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Tully M, Moffat K, Chiu C, Waters R, Gray A, Azhar M, Mioulet V, Newman J, Asfor AS, Burman A, Crossley S, Hammond JA, Tchilian E, Charleston B, Bailey D, Tuthill TJ, Graham SP, Duyvesteyn HME, Malinauskas T, Huo J, Tree JA, Buttigieg KR, Owens RJ, Carroll MW, Daniels RS, McCauley JW, Stuart DI, Huang KA, Howarth M, Townsend AR. Tan TK, et al. Among authors: howarth m. Nat Commun. 2021 Jan 22;12(1):542. doi: 10.1038/s41467-020-20654-7. Nat Commun. 2021. PMID: 33483491 Free PMC article.
DogCatcher allows loop-friendly protein-protein ligation.
Keeble AH, Yadav VK, Ferla MP, Bauer CC, Chuntharpursat-Bon E, Huang J, Bon RS, Howarth M. Keeble AH, et al. Among authors: howarth m. Cell Chem Biol. 2022 Feb 17;29(2):339-350.e10. doi: 10.1016/j.chembiol.2021.07.005. Epub 2021 Jul 28. Cell Chem Biol. 2022. PMID: 34324879 Free PMC article.
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology.
Hills RA, Kit Tan T, Cohen AA, Keeffe JR, Keeble AH, Gnanapragasam PNP, Storm KN, Hill ML, Liu S, Gilbert-Jaramillo J, Afzal M, Napier A, James WS, Bjorkman PJ, Townsend AR, Howarth M. Hills RA, et al. Among authors: howarth m. bioRxiv [Preprint]. 2023 Feb 24:2023.02.24.529520. doi: 10.1101/2023.02.24.529520. bioRxiv. 2023. Update in: Nat Nanotechnol. 2024 Aug;19(8):1216-1223. doi: 10.1038/s41565-024-01655-9. PMID: 36865256 Free PMC article. Updated. Preprint.
164 results