Johnson LT - Search Results

1

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing.

Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Liu S, et al. Among authors: johnson lt. Nat Mater. 2021 May;20(5):701-710. doi: 10.1038/s41563-020-00886-0. Epub 2021 Feb 4. Nat Mater. 2021. PMID: 33542471 Free PMC article.

2

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing.

Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Cheng Q, et al. Among authors: johnson lt. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. Nat Nanotechnol. 2020. PMID: 32251383 Free PMC article.

3

Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles.

Zhou K, Johnson LT, Xiong H, Barrios S, Minnig JT, Yan Y, Abram B, Yu X, Siegwart DJ. Zhou K, et al. Among authors: johnson lt. Mol Pharm. 2020 May 4;17(5):1575-1585. doi: 10.1021/acs.molpharmaceut.9b01288. Epub 2020 Apr 23. Mol Pharm. 2020. PMID: 32267707

4

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo.

Lee SM, Cheng Q, Yu X, Liu S, Johnson LT, Siegwart DJ. Lee SM, et al. Among authors: johnson lt. Angew Chem Int Ed Engl. 2021 Mar 8;60(11):5848-5853. doi: 10.1002/anie.202013927. Epub 2021 Feb 1. Angew Chem Int Ed Engl. 2021. PMID: 33305471 Free PMC article.

5

All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo.

Farbiak L, Cheng Q, Wei T, Álvarez-Benedicto E, Johnson LT, Lee S, Siegwart DJ. Farbiak L, et al. Among authors: johnson lt. Adv Mater. 2021 Jul;33(30):e2006619. doi: 10.1002/adma.202006619. Epub 2021 Jun 17. Adv Mater. 2021. PMID: 34137093 Free PMC article.

6

Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration.

Yu X, Liu S, Cheng Q, Lee SM, Wei T, Zhang D, Farbiak L, Johnson LT, Wang X, Siegwart DJ. Yu X, et al. Among authors: johnson lt. Pharmaceutics. 2021 Nov 12;13(11):1914. doi: 10.3390/pharmaceutics13111914. Pharmaceutics. 2021. PMID: 34834329 Free PMC article.

7

Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes.

Liu S, Wang X, Yu X, Cheng Q, Johnson LT, Chatterjee S, Zhang D, Lee SM, Sun Y, Lin TC, Liu JL, Siegwart DJ. Liu S, et al. Among authors: johnson lt. J Am Chem Soc. 2021 Dec 22;143(50):21321-21330. doi: 10.1021/jacs.1c09822. Epub 2021 Dec 8. J Am Chem Soc. 2021. PMID: 34878786 Free PMC article.

8

Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA).

Álvarez-Benedicto E, Farbiak L, Márquez Ramírez M, Wang X, Johnson LT, Mian O, Guerrero ED, Siegwart DJ. Álvarez-Benedicto E, et al. Among authors: johnson lt. Biomater Sci. 2022 Jan 18;10(2):549-559. doi: 10.1039/d1bm01454d. Biomater Sci. 2022. PMID: 34904974 Free PMC article.

9

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy.

Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, Taylor AM, Xu J, Hong Y, Zhu H, Siegwart DJ. Zhang D, et al. Among authors: johnson lt. Nat Nanotechnol. 2022 Jul;17(7):777-787. doi: 10.1038/s41565-022-01122-3. Epub 2022 May 12. Nat Nanotechnol. 2022. PMID: 35551240 Free PMC article.

10

Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.

Johnson LT, Zhang D, Zhou K, Lee SM, Liu S, Dilliard SA, Farbiak L, Chatterjee S, Lin YH, Siegwart DJ. Johnson LT, et al. Mol Pharm. 2022 Nov 7;19(11):3973-3986. doi: 10.1021/acs.molpharmaceut.2c00442. Epub 2022 Sep 26. Mol Pharm. 2022. PMID: 36154076 Free PMC article.

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