Farbiak L - Search Results

1

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing.

Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Liu S, et al. Among authors: farbiak l. Nat Mater. 2021 May;20(5):701-710. doi: 10.1038/s41563-020-00886-0. Epub 2021 Feb 4. Nat Mater. 2021. PMID: 33542471 Free PMC article.

2

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I.

Cheng Q, Wei T, Jia Y, Farbiak L, Zhou K, Zhang S, Wei Y, Zhu H, Siegwart DJ. Cheng Q, et al. Among authors: farbiak l. Adv Mater. 2018 Dec;30(52):e1805308. doi: 10.1002/adma.201805308. Epub 2018 Oct 25. Adv Mater. 2018. PMID: 30368954

3

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing.

Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Cheng Q, et al. Among authors: farbiak l. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. Nat Nanotechnol. 2020. PMID: 32251383 Free PMC article.

4

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing.

Wei T, Cheng Q, Farbiak L, Anderson DG, Langer R, Siegwart DJ. Wei T, et al. Among authors: farbiak l. ACS Nano. 2020 Aug 25;14(8):9243-9262. doi: 10.1021/acsnano.0c04707. Epub 2020 Jul 22. ACS Nano. 2020. PMID: 32697075 Free PMC article.

5

All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo.

Farbiak L, Cheng Q, Wei T, Álvarez-Benedicto E, Johnson LT, Lee S, Siegwart DJ. Farbiak L, et al. Adv Mater. 2021 Jul;33(30):e2006619. doi: 10.1002/adma.202006619. Epub 2021 Jun 17. Adv Mater. 2021. PMID: 34137093 Free PMC article.

6

Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery.

Melamed JR, Hajj KA, Chaudhary N, Strelkova D, Arral ML, Pardi N, Alameh MG, Miller JB, Farbiak L, Siegwart DJ, Weissman D, Whitehead KA. Melamed JR, et al. Among authors: farbiak l. J Control Release. 2022 Jan;341:206-214. doi: 10.1016/j.jconrel.2021.11.022. Epub 2021 Nov 18. J Control Release. 2022. PMID: 34801660 Free PMC article.

7

Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration.

Yu X, Liu S, Cheng Q, Lee SM, Wei T, Zhang D, Farbiak L, Johnson LT, Wang X, Siegwart DJ. Yu X, et al. Among authors: farbiak l. Pharmaceutics. 2021 Nov 12;13(11):1914. doi: 10.3390/pharmaceutics13111914. Pharmaceutics. 2021. PMID: 34834329 Free PMC article.

8

Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA).

Álvarez-Benedicto E, Farbiak L, Márquez Ramírez M, Wang X, Johnson LT, Mian O, Guerrero ED, Siegwart DJ. Álvarez-Benedicto E, et al. Among authors: farbiak l. Biomater Sci. 2022 Jan 18;10(2):549-559. doi: 10.1039/d1bm01454d. Biomater Sci. 2022. PMID: 34904974 Free PMC article.

9

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy.

Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, Taylor AM, Xu J, Hong Y, Zhu H, Siegwart DJ. Zhang D, et al. Among authors: farbiak l. Nat Nanotechnol. 2022 Jul;17(7):777-787. doi: 10.1038/s41565-022-01122-3. Epub 2022 May 12. Nat Nanotechnol. 2022. PMID: 35551240 Free PMC article.

10

Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.

Johnson LT, Zhang D, Zhou K, Lee SM, Liu S, Dilliard SA, Farbiak L, Chatterjee S, Lin YH, Siegwart DJ. Johnson LT, et al. Among authors: farbiak l. Mol Pharm. 2022 Nov 7;19(11):3973-3986. doi: 10.1021/acs.molpharmaceut.2c00442. Epub 2022 Sep 26. Mol Pharm. 2022. PMID: 36154076 Free PMC article.

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