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Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway.
Huang H, Zhao C, Hu Q, Liu Q, Sun YM, Chen C, Huang H, Zhou CH, Wu YQ. Huang H, et al. Among authors: chen c. Mol Neurobiol. 2021 Dec;58(12):6272-6289. doi: 10.1007/s12035-021-02550-3. Epub 2021 Sep 3. Mol Neurobiol. 2021. PMID: 34480336
Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells.
Huang H, Wang N, Lin JT, Qiu YK, Wu WF, Liu Q, Chen C, Wang HB, Liu YP, Dong W, Wan J, Zheng H, Zhou CH, Wu YQ. Huang H, et al. Among authors: chen c. Mol Neurobiol. 2024 Aug;61(8):5459-5480. doi: 10.1007/s12035-024-03921-2. Epub 2024 Jan 10. Mol Neurobiol. 2024. PMID: 38200350
Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine.
Wan J, Ma L, Jiao X, Dong W, Lin J, Qiu Y, Wu W, Liu Q, Chen C, Huang H, Li S, Zheng H, Wu Y. Wan J, et al. Among authors: chen c. CNS Neurosci Ther. 2024 Feb;30(2):e14604. doi: 10.1111/cns.14604. CNS Neurosci Ther. 2024. PMID: 38332635 Free PMC article.
Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction.
Wu WF, Chen C, Lin JT, Jiao XH, Dong W, Wan J, Liu Q, Qiu YK, Sun A, Liu YQ, Jin CH, Huang H, Zheng H, Zhou CH, Wu YQ. Wu WF, et al. Among authors: chen c. Cell Mol Biol Lett. 2024 May 23;29(1):79. doi: 10.1186/s11658-024-00595-5. Cell Mol Biol Lett. 2024. PMID: 38783169 Free PMC article.
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