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Deep convolutional neural networks to predict cardiovascular risk from computed tomography.
Zeleznik R, Foldyna B, Eslami P, Weiss J, Alexander I, Taron J, Parmar C, Alvi RM, Banerji D, Uno M, Kikuchi Y, Karady J, Zhang L, Scholtz JE, Mayrhofer T, Lyass A, Mahoney TF, Massaro JM, Vasan RS, Douglas PS, Hoffmann U, Lu MT, Aerts HJWL. Zeleznik R, et al. Among authors: alexander i. Nat Commun. 2021 Jan 29;12(1):715. doi: 10.1038/s41467-021-20966-2. Nat Commun. 2021. PMID: 33514711 Free PMC article.
AAVolve: Concatenated long-read deep sequencing enables whole capsid tracking during shuffled AAV library selection.
Scott S, Westhaus A, Nazareth D, Cabanes-Creus M, Navarro RG, Chandra D, Zhu E, Venkateswaran A, Alexander IE, Bauer DC, Wilson LOW, Lisowski L. Scott S, et al. Among authors: alexander ie. Mol Ther Methods Clin Dev. 2024 Oct 4;32(4):101351. doi: 10.1016/j.omtm.2024.101351. eCollection 2024 Dec 12. Mol Ther Methods Clin Dev. 2024. PMID: 39498467 Free PMC article.
Gene therapy clinical trials worldwide to 2023-an update.
Ginn SL, Mandwie M, Alexander IE, Edelstein M, Abedi MR. Ginn SL, et al. Among authors: alexander ie. J Gene Med. 2024 Aug;26(8):e3721. doi: 10.1002/jgm.3721. J Gene Med. 2024. PMID: 39114903 Review.
Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.
Zakas PM, Cunningham SC, Doherty A, van Dijk EB, Ibraheim R, Yu S, Mekonnen BD, Lang B, English EJ, Sun G, Duncan MC, Benczkowski MS, Altshuler RC, Singh MJ, Kibbler ES, Tonga GY, Wang ZJ, Wang ZJ, Li G, An D, Rottman JB, Bhavsar Y, Purcell C, Jain R, Alberry R, Roquet N, Fu Y, Citorik RJ, Rubens JR, Holmes MC, Cotta-Ramusino C, Querbes W, Alexander IE, Salomon WE. Zakas PM, et al. Among authors: alexander ie. Mol Ther. 2024 Oct 2;32(10):3356-3371. doi: 10.1016/j.ymthe.2024.06.021. Epub 2024 Jul 8. Mol Ther. 2024. PMID: 38981468
Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing.
Mietzsch M, Nelson AR, Hsi J, Zachary J, Potts L, Chipman P, Ghanem M, Khandekar N, Alexander IE, Logan GJ, Huiskonen JT, McKenna R. Mietzsch M, et al. Among authors: alexander ie. bioRxiv [Preprint]. 2024 May 3:2024.05.01.590489. doi: 10.1101/2024.05.01.590489. bioRxiv. 2024. PMID: 38746165 Free PMC article. Preprint.
392 results