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SHP2 protects endothelial cell barrier through suppressing VE-cadherin internalization regulated by MET-ARF1.
Zhang J, Huang J, Qi T, Huang Y, Lu Y, Zhan T, Gong H, Zhu Z, Shi Y, Zhou J, Yu L, Zhang X, Cheng H, Ke Y. Zhang J, et al. Among authors: zhou j. FASEB J. 2019 Jan;33(1):1124-1137. doi: 10.1096/fj.201800284R. Epub 2018 Aug 13. FASEB J. 2019. PMID: 30102570
Together, our findings define a novel role of SHP2 in stabilizing junctional VE-cadherin in the resting endothelial barrier through suppressing MET and ARF1 activation.-Zhang, J., Huang, J., Qi, T., Huang, Y., Lu, Y., Zhan, T., Gong, H., Zhu, Z., Shi, Y., Zhou …
Together, our findings define a novel role of SHP2 in stabilizing junctional VE-cadherin in the resting endothelial barrier through suppress …
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