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Page 1
Factors Associated with Frequent Exacerbations in the UK Severe Asthma Registry.
Yang F, Busby J, Heaney LG, Menzies-Gow A, Pfeffer PE, Jackson DJ, Mansur AH, Siddiqui S, Brightling CE, Niven R, Thomson NC, Chaudhuri R; UK Severe Asthma Registry. Yang F, et al. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2691-2701.e1. doi: 10.1016/j.jaip.2020.12.062. Epub 2021 Jan 15. J Allergy Clin Immunol Pract. 2021. PMID: 33460858 Free article.
Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.
Heaney LG, Busby J, Hanratty CE, Djukanovic R, Woodcock A, Walker SM, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Mansur AH, Fowler SJ, Niven RM, Howarth PH, Lordan JL, Menzies-Gow A, Harrison TW, Robinson DS, Holweg CTJ, Matthews JG, Pavord ID; investigators for the MRC Refractory Asthma Stratification Programme. Heaney LG, et al. Lancet Respir Med. 2021 Jan;9(1):57-68. doi: 10.1016/S2213-2600(20)30397-0. Epub 2020 Sep 8. Lancet Respir Med. 2021. PMID: 32916135 Free PMC article. Clinical Trial.
The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?
Smith SJ, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Yang F, Fowler SJ, Menzies-Gow A, Idris E, Brown T, Gore R, Faruqi S, Dennison P, Dodd JW, Doe S, Mansur AH, Priyadarshi R, Holmes J, Hearn A, Al-Aqqad H, Loewenthal L, Cooper A, Fox L, Selvan M, Crooks MG, Thompson A, Higbee D, Fawdon M, Nathwani V, Holmes L, Chaudhuri R. Smith SJ, et al. Among authors: yang f. ERJ Open Res. 2021 Feb 1;7(1):00768-2020. doi: 10.1183/23120541.00768-2020. eCollection 2021 Jan. ERJ Open Res. 2021. PMID: 33564672 Free PMC article.
The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study.
McDowell PJ, Diver S, Yang F, Borg C, Busby J, Brown V, Shrimanker R, Cox C, Brightling CE, Chaudhuri R, Pavord ID, Heaney LG; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium). McDowell PJ, et al. Among authors: yang f. Lancet Respir Med. 2021 Oct;9(10):1174-1184. doi: 10.1016/S2213-2600(21)00004-7. Epub 2021 May 7. Lancet Respir Med. 2021. PMID: 33971168
Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation.
Diver S, Haldar K, McDowell PJ, Busby J, Mistry V, Micieli C, Brown V, Cox C, Yang F, Borg C, Shrimanker R, Ramsheh MY, Hardman T, Arron J, Bradding P, Cowan D, Mansur AH, Fowler SJ, Lordan J, Menzies-Gow A, Robinson D, Matthews J, Pavord ID, Chaudhuri R, Heaney LG, Barer MR, Brightling C; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium). Diver S, et al. Among authors: yang f. Allergy. 2022 Nov;77(11):3362-3376. doi: 10.1111/all.15425. Epub 2022 Jul 15. Allergy. 2022. PMID: 35778780 Free article.
Anti-IL-5 therapies for asthma.
Farne HA, Wilson A, Milan S, Banchoff E, Yang F, Powell CV. Farne HA, et al. Among authors: yang f. Cochrane Database Syst Rev. 2022 Jul 12;7(7):CD010834. doi: 10.1002/14651858.CD010834.pub4. Cochrane Database Syst Rev. 2022. PMID: 35838542 Free PMC article. Review.
Corticosteroid Responsiveness Following Mepolizumab in Severe Eosinophilic Asthma-A Randomized, Placebo-Controlled Crossover Trial (MAPLE).
Yang F, Busby J, Heaney LG, Pavord ID, Brightling CE, Borg K, McDowell JP, Diver SE, Shrimanker R, Bradding P, Shepherd M, Chaudhuri R; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium). Yang F, et al. J Allergy Clin Immunol Pract. 2022 Nov;10(11):2925-2934.e12. doi: 10.1016/j.jaip.2022.06.050. Epub 2022 Jul 19. J Allergy Clin Immunol Pract. 2022. PMID: 35863669 Free article. Clinical Trial.
Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study.
Djukanović R, Brinkman P, Kolmert J, Gomez C, Schofield J, Brandsma J, Shapanis A, Skipp PJS, Postle A, Wheelock C, Dahlen SE, Sterk PJ, Brown T, Jackson DJ, Mansur A, Pavord I, Patel M, Brightling C, Siddiqui S, Bradding P, Sabroe I, Saralaya D, Chishimba L, Porter J, Robinson D, Fowler S, Howarth PH, Little L, Oliver T, Hill K, Stanton L, Allen A, Ellis D, Griffiths G, Harrison T, Akenroye A, Lasky-Su J, Heaney L, Chaudhuri R, Kurukulaaratchy R; SoMOSA study team and the U-BIOPRED study team. Djukanović R, et al. Am J Respir Crit Care Med. 2024 Aug 1;210(3):288-297. doi: 10.1164/rccm.202310-1730OC. Am J Respir Crit Care Med. 2024. PMID: 38635834 Free PMC article.
Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma.
Howell I, Yang F, Brown V, Cane J, Marchi E, Azim A, Busby J, McDowell PJ, Diver SE, Borg C, Heaney LG, Pavord ID, Brightling CE, Chaudhuri R, Hinks TSC. Howell I, et al. Among authors: yang f. J Allergy Clin Immunol. 2024 Nov;154(5):1146-1158. doi: 10.1016/j.jaci.2024.07.020. Epub 2024 Aug 2. J Allergy Clin Immunol. 2024. PMID: 39097197 Free article. Clinical Trial.
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