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Page 1
Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG. Bonekamp NA, et al. Among authors: di lucrezia r. Nature. 2020 Dec;588(7839):712-716. doi: 10.1038/s41586-020-03048-z. Epub 2020 Dec 16. Nature. 2020. PMID: 33328633
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Sollberger G, Choidas A, Burn GL, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Krüger R, Herzig A, Zychlinsky A. Sollberger G, et al. Among authors: di lucrezia r. Sci Immunol. 2018 Aug 24;3(26):eaar6689. doi: 10.1126/sciimmunol.aar6689. Sci Immunol. 2018. PMID: 30143555
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG. Jiang S, et al. Among authors: di lucrezia r. Nat Metab. 2024 Jun;6(6):1024-1035. doi: 10.1038/s42255-024-01038-3. Epub 2024 Apr 30. Nat Metab. 2024. PMID: 38689023 Free PMC article.
Potent agonists of the Hedgehog signaling pathway.
Brunton SA, Stibbard JH, Rubin LL, Guicherit OM, Kruse LI, Price S, di Lucrezia R, MacKinnon CH, Avery A, Park Y, Buxton D, Boyd EA. Brunton SA, et al. Among authors: di lucrezia r. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4308-11. doi: 10.1016/j.bmcl.2009.05.096. Epub 2009 May 29. Bioorg Med Chem Lett. 2009. PMID: 19500978
Novel inhibitors of Leishmanial dihydrofolate reductase.
Chowdhury SF, Di Lucrezia R, Guerrero RH, Brun R, Goodman J, Ruiz-Perez LM, Pacanowska DG, Gilbert IH. Chowdhury SF, et al. Among authors: di lucrezia r. Bioorg Med Chem Lett. 2001 Apr 23;11(8):977-80. doi: 10.1016/s0960-894x(01)00089-0. Bioorg Med Chem Lett. 2001. PMID: 11327604
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Zuccotto F, Zvelebil M, Brun R, Chowdhury SF, Di Lucrezia R, Leal I, Maes L, Ruiz-Perez LM, Gonzalez Pacanowska D, Gilbert IH. Zuccotto F, et al. Among authors: di lucrezia r. Eur J Med Chem. 2001 May;36(5):395-405. doi: 10.1016/s0223-5234(01)01235-1. Eur J Med Chem. 2001. PMID: 11451529