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Kinomic profiling of tumour xenografts derived from patients with non-small cell lung cancer confirms their fidelity and reveals potentially actionable pathways.
Tabbò F, Guerrera F, van den Berg A, Gaudiano M, Maletta F, Bessone L, Nottegar A, Costardi L, de Wijn R, Ruijtenbeek R, Delsedime L, Sapino A, Ruffini E, Hilhorst R, Inghirami G. Tabbò F, et al. Among authors: de wijn r. Eur J Cancer. 2021 Feb;144:17-30. doi: 10.1016/j.ejca.2020.10.036. Epub 2020 Dec 11. Eur J Cancer. 2021. PMID: 33316635
Kinome profiling in pediatric brain tumors as a new approach for target discovery.
Sikkema AH, Diks SH, den Dunnen WF, ter Elst A, Scherpen FJ, Hoving EW, Ruijtenbeek R, Boender PJ, de Wijn R, Kamps WA, Peppelenbosch MP, de Bont ES. Sikkema AH, et al. Among authors: de wijn r, de bont es. Cancer Res. 2009 Jul 15;69(14):5987-95. doi: 10.1158/0008-5472.CAN-08-3660. Epub 2009 Jun 30. Cancer Res. 2009. PMID: 19567681
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M. Eriksson A, et al. Among authors: de wijn r. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. Biochem Pharmacol. 2014. PMID: 24200998 Free article. Clinical Trial.
Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance.
Krayem M, Aftimos P, Najem A, van den Hooven T, van den Berg A, Hovestad-Bijl L, de Wijn R, Hilhorst R, Ruijtenbeek R, Sabbah M, Kerger J, Awada A, Journe F, Ghanem GE. Krayem M, et al. Among authors: de wijn r. Cancers (Basel). 2020 Feb 22;12(2):512. doi: 10.3390/cancers12020512. Cancers (Basel). 2020. PMID: 32098410 Free PMC article.
Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.
Hurkmans DP, Verdegaal EME, Hogan SA, de Wijn R, Hovestad L, van den Heuvel DMA, Ruijtenbeek R, Welters MJP, van Brakel M, Basak EA, Pinedo HM, Lamers CHJ, van de Werken HJG, Groten JP, Debets R, Levesque MP, Dummer R, Kapiteijn E, Mathijssen RHJ, Aerts JGJV, van der Burg SH. Hurkmans DP, et al. Among authors: de wijn r. J Immunother Cancer. 2020 Dec;8(2):e001607. doi: 10.1136/jitc-2020-001607. J Immunother Cancer. 2020. PMID: 33427690 Free PMC article.
Time dependent effect of cold ischemia on the phosphoproteome and protein kinase activity in fresh-frozen colorectal cancer tissue obtained from patients.
Buffart TE, van den Oord RAHM, van den Berg A, Hilhorst R, Bastiaensen N, Pruijt HFM, van den Brule A, Nooijen P, Labots M, de Goeij-de Haas RR, Dekker H, Piersma SR, Pham TV, van der Leij T, de Wijn R, Ruijtenbeek R, Jiménez CR, Verheul HMW. Buffart TE, et al. Among authors: de wijn r, de goeij de haas rr. Clin Proteomics. 2021 Feb 18;18(1):8. doi: 10.1186/s12014-020-09306-6. Clin Proteomics. 2021. PMID: 33602116 Free PMC article.
Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src family kinases as prognostic markers and potential targets.
Bußmann L, Hoffer K, von Bargen CM, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu AT, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann LC, Zech HB, Berger JC, Möckelmann N, Busch CJ, Böttcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz TS, Betz CS, Petersen C, Rothkamm K, Münscher A, Kriegs M. Bußmann L, et al. Among authors: de wijn r. Int J Cancer. 2021 Sep 1;149(5):1166-1180. doi: 10.1002/ijc.33606. Epub 2021 May 7. Int J Cancer. 2021. PMID: 33890294
Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling.
Folkvord S, Flatmark K, Dueland S, de Wijn R, Grøholt KK, Hole KH, Nesland JM, Ruijtenbeek R, Boender PJ, Johansen M, Giercksky KE, Ree AH. Folkvord S, et al. Among authors: de wijn r. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):555-62. doi: 10.1016/j.ijrobp.2010.04.036. Epub 2010 Aug 2. Int J Radiat Oncol Biol Phys. 2010. PMID: 20675069
KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA.
Anderson JC, Taylor RB, Fiveash JB, de Wijn R, Gillespie GY, Willey CD. Anderson JC, et al. Among authors: de wijn r. Med Res Arch. 2015 Jul;2015(3):10.18103/mra.v0i3.104. doi: 10.18103/mra.v0i3.104. Med Res Arch. 2015. PMID: 27158663 Free PMC article.
56 results