Zhao R - Search Results

1

First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo.

Wei M, Zhao R, Cao Y, Wei Y, Li M, Dong Z, Liu Y, Ruan H, Li Y, Cao S, Tang Z, Zhou Y, Song W, Wang Y, Wang J, Yang G, Yang C. Wei M, et al. Among authors: zhao r. Eur J Med Chem. 2021 Jan 1;209:112903. doi: 10.1016/j.ejmech.2020.112903. Epub 2020 Oct 9. Eur J Med Chem. 2021. PMID: 33256948

2

Combination of amino acid/dipeptide with ligustrazine-betulinic acid as antitumor agents.

Xu B, Yan WQ, Xu X, Wu GR, Zhang CZ, Han YT, Chu FH, Zhao R, Wang PL, Lei HM. Xu B, et al. Among authors: zhao r. Eur J Med Chem. 2017 Apr 21;130:26-38. doi: 10.1016/j.ejmech.2017.02.036. Epub 2017 Feb 17. Eur J Med Chem. 2017. PMID: 28237794

3

A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.

Liu S, Gao X, Zhang L, Qin S, Wei M, Liu N, Zhao R, Li B, Meng Y, Lin G, Lu C, Liu X, Xie M, Liu T, Zhou H, Qi M, Yang G, Yang C. Liu S, et al. Among authors: zhao r. Eur J Med Chem. 2018 Aug 5;156:21-42. doi: 10.1016/j.ejmech.2018.06.046. Epub 2018 Jun 20. Eur J Med Chem. 2018. PMID: 30006166

4

Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.

Liu X, Li B, Zhang Z, Wei Y, Xu Z, Qin S, Liu N, Zhao R, Peng J, Yang G, Qi M, Liu T, Xie M, Liu S, Gao X, Lu C, Zhu L, Long X, Kang H, Sun T, Zhou H, Wei M, Yang G, Yang C. Liu X, et al. Among authors: zhao r. J Med Chem. 2018 Dec 13;61(23):10814-10833. doi: 10.1021/acs.jmedchem.8b01445. Epub 2018 Nov 29. J Med Chem. 2018. PMID: 30433783

5

Synthesis and biological activities evaluation of sanjuanolide and its analogues.

Zhai J, Fu L, Li Y, Zhao R, Wang R, Deng H, Liu H, Kong L, Chen Z, Sang F. Zhai J, et al. Among authors: zhao r. Bioorg Med Chem Lett. 2019 Jan 15;29(2):326-328. doi: 10.1016/j.bmcl.2018.11.020. Epub 2018 Nov 10. Bioorg Med Chem Lett. 2019. PMID: 30472027

6

Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.

Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, Li B, Wang J, Song Y, Chong C, Zhao R, Wang J, Yu L, Yang G, Yang C. Wei M, et al. Among authors: zhao r. Eur J Med Chem. 2020 Nov 15;206:112677. doi: 10.1016/j.ejmech.2020.112677. Epub 2020 Aug 1. Eur J Med Chem. 2020. PMID: 32823005

7

Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.

Li J, Zhao R, Miao P, Xu F, Chen J, Jiang X, Hui Z, Wang L, Bai R. Li J, et al. Among authors: zhao r. Eur J Med Chem. 2023 Nov 15;260:115791. doi: 10.1016/j.ejmech.2023.115791. Epub 2023 Sep 4. Eur J Med Chem. 2023. PMID: 37683361 Review.

8

Synthesis of the novel elemonic acid derivatives as Pin1 inhibitors.

Li X, Li L, Zhou Q, Zhang N, Zhang S, Zhao R, Liu D, Jing Y, Zhao L. Li X, et al. Among authors: zhao r, zhao l. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5612-5615. doi: 10.1016/j.bmcl.2014.10.087. Epub 2014 Nov 1. Bioorg Med Chem Lett. 2014. PMID: 25466185

9

Neuroprotection by new ligustrazine-cinnamon acid derivatives on CoCl₂-induced apoptosis in differentiated PC12 cells.

Wang P, Zhao R, Yan W, Zhang X, Zhang H, Xu B, Chu F, Han Y, Li G, Liu W, Zhang Y, Lei H. Wang P, et al. Among authors: zhao r. Bioorg Chem. 2018 Apr;77:360-369. doi: 10.1016/j.bioorg.2018.01.029. Epub 2018 Feb 2. Bioorg Chem. 2018. PMID: 29421712

10

HDAC1/MAO-B dual inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.

Yao C, Jiang X, Zhao R, Zhong Z, Ge J, Zhu J, Ye XY, Xie Y, Liu Z, Xie T, Bai R. Yao C, et al. Among authors: zhao r. Bioorg Chem. 2022 May;122:105724. doi: 10.1016/j.bioorg.2022.105724. Epub 2022 Mar 15. Bioorg Chem. 2022. PMID: 35305483

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