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653 results

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Page 1
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition.
Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: osaki y. Cell Mol Gastroenterol Hepatol. 2021;11(4):949-971. doi: 10.1016/j.jcmgh.2020.11.004. Epub 2020 Nov 24. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33246135 Free PMC article.
Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.
Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H. Osaki Y, et al. Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14. Biochem Biophys Res Commun. 2015. PMID: 26381177
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.
Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han SI, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: osaki y. Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857. Sci Rep. 2016. PMID: 27291420 Free PMC article.
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H. Kikuchi T, et al. Among authors: osaki y. Mol Metab. 2016 Sep 17;5(11):1092-1102. doi: 10.1016/j.molmet.2016.09.004. eCollection 2016 Nov. Mol Metab. 2016. PMID: 27818935 Free PMC article.
Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.
Takei K, Han SI, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H. Takei K, et al. Among authors: osaki y. J Diabetes Investig. 2017 Jul;8(4):446-452. doi: 10.1111/jdi.12621. Epub 2017 Apr 25. J Diabetes Investig. 2017. PMID: 28084058 Free PMC article.
Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H. Matsuzaka T, et al. Among authors: osaki y. Hepatology. 2020 May;71(5):1609-1625. doi: 10.1002/hep.30953. Epub 2020 Feb 7. Hepatology. 2020. PMID: 31529722
Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.
Ma Y, Sekiya M, Kainoh K, Matsuda T, Iwasaki H, Osaki Y, Sugano Y, Suzuki H, Takeuchi Y, Miyamoto T, Yahagi N, Nakagawa Y, Matsuzaka T, Shimano H. Ma Y, et al. Among authors: osaki y. Biochem Biophys Res Commun. 2020 Mar 5;523(2):354-360. doi: 10.1016/j.bbrc.2019.12.070. Epub 2019 Dec 19. Biochem Biophys Res Commun. 2020. PMID: 31866012
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms.
Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H. Satoh A, et al. Among authors: osaki y. iScience. 2020 Mar 27;23(3):100930. doi: 10.1016/j.isci.2020.100930. Epub 2020 Feb 21. iScience. 2020. PMID: 32151974 Free PMC article.
CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.
Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H. Kainoh K, et al. Among authors: osaki y. Biochem Biophys Res Commun. 2021 Jul 12;562:146-153. doi: 10.1016/j.bbrc.2021.05.069. Epub 2021 May 27. Biochem Biophys Res Commun. 2021. PMID: 34052660
Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.
Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H. Okajima Y, et al. Among authors: osaki y. Biochim Biophys Acta Mol Basis Dis. 2022 Apr 1;1868(4):166339. doi: 10.1016/j.bbadis.2022.166339. Epub 2022 Jan 8. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35017029 Free article.
653 results