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Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis.
Overstreet JM, Wang Y, Wang X, Niu A, Gewin LS, Yao B, Harris RC, Zhang MZ. Overstreet JM, et al. Among authors: niu a. FASEB J. 2017 Oct;31(10):4407-4421. doi: 10.1096/fj.201601359RR. Epub 2017 Jun 16. FASEB J. 2017. PMID: 28626027 Free PMC article.
Furthermore, EGFR activation in epithelial cells promoted the proliferation of alpha-SMA(+) myofibroblasts in a paracrine manner. Genetic or pharmacologic inhibition of EGFR tyrosine kinase activity or downstream MEK activity attenuated the fibrotic phenotype. This study p …
Furthermore, EGFR activation in epithelial cells promoted the proliferation of alpha-SMA(+) myofibroblasts in a paracrine manner. Gen …
The Role of the EGF Receptor in Sex Differences in Kidney Injury.
Zhang MZ, Sasaki K, Li Y, Li Z, Pan Y, Jin GN, Wang Y, Niu A, Wang S, Fan X, Chen JC, Borza C, Yang H, Pozzi A, Fogo AB, Harris RC. Zhang MZ, et al. Among authors: niu a. J Am Soc Nephrol. 2019 Sep;30(9):1659-1673. doi: 10.1681/ASN.2018121244. Epub 2019 Jul 10. J Am Soc Nephrol. 2019. PMID: 31292196 Free PMC article.
Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation.
Sasaki K, Terker AS, Pan Y, Li Z, Cao S, Wang Y, Niu A, Wang S, Fan X, Zhang MZ, Harris RC. Sasaki K, et al. Among authors: niu a. J Am Soc Nephrol. 2021 May 3;32(5):1037-1052. doi: 10.1681/ASN.2020071010. Epub 2021 Feb 22. J Am Soc Nephrol. 2021. PMID: 33619052 Free PMC article.
193 results