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The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses.
Weston S, Baracco L, Keller C, Matthews K, McGrath ME, Logue J, Liang J, Dyall J, Holbrook MR, Hensley LE, Jahrling PB, Yu W, MacKerell AD Jr, Frieman MB. Weston S, et al. Among authors: jahrling pb. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30687-30698. doi: 10.1073/pnas.2012939117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184176 Free PMC article.
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.
Dyall J, Coleman CM, Hart BJ, Venkataraman T, Holbrook MR, Kindrachuk J, Johnson RF, Olinger GG Jr, Jahrling PB, Laidlaw M, Johansen LM, Lear-Rooney CM, Glass PJ, Hensley LE, Frieman MB. Dyall J, et al. Among authors: jahrling pb. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. doi: 10.1128/AAC.03036-14. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841273 Free PMC article.
Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis.
Kindrachuk J, Ork B, Hart BJ, Mazur S, Holbrook MR, Frieman MB, Traynor D, Johnson RF, Dyall J, Kuhn JH, Olinger GG, Hensley LE, Jahrling PB. Kindrachuk J, et al. Among authors: jahrling pb. Antimicrob Agents Chemother. 2015 Feb;59(2):1088-99. doi: 10.1128/AAC.03659-14. Epub 2014 Dec 8. Antimicrob Agents Chemother. 2015. PMID: 25487801 Free PMC article.
Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs.
Postnikova E, Cong Y, DeWald LE, Dyall J, Yu S, Hart BJ, Zhou H, Gross R, Logue J, Cai Y, Deiuliis N, Michelotti J, Honko AN, Bennett RS, Holbrook MR, Olinger GG, Hensley LE, Jahrling PB. Postnikova E, et al. Among authors: jahrling pb. PLoS One. 2018 Mar 22;13(3):e0194880. doi: 10.1371/journal.pone.0194880. eCollection 2018. PLoS One. 2018. PMID: 29566079 Free PMC article.
316 results