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Prednisolone or pentoxifylline for alcoholic hepatitis.
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial. Thursz MR, et al. Among authors: vergis n. N Engl J Med. 2015 Apr 23;372(17):1619-28. doi: 10.1056/NEJMoa1412278. N Engl J Med. 2015. PMID: 25901427 Free article. Clinical Trial.
In severe alcohol-related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using IL-8 and micro-RNAs.
Tyson LD, Atkinson S, Hunter RW, Allison M, Austin A, Dear JW, Forrest E, Liu T, Lord E, Masson S, Nunes J, Richardson P, Ryder SD, Wright M, Thursz M, Vergis N. Tyson LD, et al. Among authors: vergis n. Aliment Pharmacol Ther. 2023 Dec;58(11-12):1217-1229. doi: 10.1111/apt.17733. Epub 2023 Oct 2. Aliment Pharmacol Ther. 2023. PMID: 37781965 Free PMC article.
IL-1 Signal Inhibition in Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial of Canakinumab.
Vergis N, Patel V, Bogdanowicz K, Czyzewska-Khan J, Keshinro R, Fiorentino F, Day E, Middleton P, Atkinson S, Tranah T, Cross M, Babalis D, Foster N, Lord E, Quaglia A, Lloyd J, Goldin R, Rosenberg W, Parker R, Richardson P, Masson S, Whitehouse G, Sieberhagan C, Patch D, Naoumov N, Dhanda A, Forrest E, Thursz M. Vergis N, et al. Clin Gastroenterol Hepatol. 2024 Aug 23:S1542-3565(24)00759-6. doi: 10.1016/j.cgh.2024.07.025. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 39181422 Free article.
The Liverpool alcohol-related liver disease algorithm identifies twice as many emergency admissions compared to standard methods when applied to Hospital Episode Statistics for England.
Dhanda A, Bodger K, Hood S, Henn C, Allison M, Amasiatu C, Burton R, Cramp M, Forrest E, Khetani M, MacGilchrist A, Masson S, Parker R, Sheron N, Simpson K, Vergis N, White M; BASL ARLD SIG National Service Evaluation Group. Dhanda A, et al. Among authors: vergis n. Aliment Pharmacol Ther. 2023 Feb;57(4):368-377. doi: 10.1111/apt.17307. Epub 2022 Nov 17. Aliment Pharmacol Ther. 2023. PMID: 36397658 Free PMC article.
42 results