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Page 1
Drugging the Next Undruggable KRAS Allele-Gly12Asp.
Zheng Q, Peacock DM, Shokat KM. Zheng Q, et al. Among authors: peacock dm. J Med Chem. 2022 Feb 24;65(4):3119-3122. doi: 10.1021/acs.jmedchem.2c00099. Epub 2022 Feb 15. J Med Chem. 2022. PMID: 35167298 Review.
KRAS is vulnerable to reversible switch-II pocket engagement in cells.
Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM. Vasta JD, et al. Among authors: peacock dm. Nat Chem Biol. 2022 Jun;18(6):596-604. doi: 10.1038/s41589-022-00985-w. Epub 2022 Mar 21. Nat Chem Biol. 2022. PMID: 35314814 Free PMC article.
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM. Morstein J, et al. Among authors: peacock dm. Cell. 2024 Oct 31;187(22):6379-6392.e17. doi: 10.1016/j.cell.2024.08.017. Epub 2024 Sep 9. Cell. 2024. PMID: 39255801 Free PMC article.