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An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease.
Ruotsalainen SE, Partanen JJ, Cichonska A, Lin J, Benner C, Surakka I; FinnGen; Reeve MP, Palta P, Salmi M, Jalkanen S, Ahola-Olli A, Palotie A, Salomaa V, Daly MJ, Pirinen M, Ripatti S, Koskela J. Ruotsalainen SE, et al. Among authors: cichonska a. Eur J Hum Genet. 2021 Feb;29(2):309-324. doi: 10.1038/s41431-020-00730-8. Epub 2020 Oct 27. Eur J Hum Genet. 2021. PMID: 33110245 Free PMC article.
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.
Cichonska A, Rousu J, Marttinen P, Kangas AJ, Soininen P, Lehtimäki T, Raitakari OT, Järvelin MR, Salomaa V, Ala-Korpela M, Ripatti S, Pirinen M. Cichonska A, et al. Bioinformatics. 2016 Jul 1;32(13):1981-9. doi: 10.1093/bioinformatics/btw052. Epub 2016 Feb 19. Bioinformatics. 2016. PMID: 27153689 Free PMC article.
MOTIVATION: A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. ...Currently, modest sample sizes of individual cohorts, and restricted availability of individual-level genotype-phenotype data across the cohor …
MOTIVATION: A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. ...Cu …
Circulating Metabolic Biomarkers Are Consistently Associated With Type 2 Diabetes Risk in Asian and European Populations.
Seah JYH, Hong Y, Cichońska A, Sabanayagam C, Nusinovici S, Wong TY, Cheng CY, Jousilahti P, Lundqvist A, Perola M, Salomaa V, Tai ES, Würtz P, van Dam RM, Sim X. Seah JYH, et al. Among authors: cichonska a. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e2751-e2761. doi: 10.1210/clinem/dgac212. J Clin Endocrinol Metab. 2022. PMID: 35390150
Modeling drug combination effects via latent tensor reconstruction.
Wang T, Szedmak S, Wang H, Aittokallio T, Pahikkala T, Cichonska A, Rousu J. Wang T, et al. Among authors: cichonska a. Bioinformatics. 2021 Jul 12;37(Suppl_1):i93-i101. doi: 10.1093/bioinformatics/btab308. Bioinformatics. 2021. PMID: 34252952 Free PMC article.
17 results